Chirallica D.o.o.

Societa' Cooperative Centro Ricerche Polytech a Responsabilitia' Limitata

Industrie Chimiche Capparo S.p.a.

Vitomir Sunjic

Vladimir Vinkovic

Darko Kontrec

Luciano Navarini

Amir Avdagic

Zdenko Hamersak

Paolo Mariotti

Maja Majeric

The invention describes new chiral stationary phases containing a 4-amino-3,5-dinitrobenzoic unit modified with chiral groups and spacer groups. The invention includes the process for the preparation of said stationary phases starting from 4-halogenated derivative of 3,5-dinitrobenzoic acid, chiral selectors obtainable as intermediates in the aforesaid process, and the use of the chiral stationary phases in the separation of enantiomers.

Chiral stationary phases based on derivatives of 4-amino-3,5-dinitrobenzoic acid

The present invention describes new chiral stationary phases and optically active compounds therein contained. The optically active compounds contained in the stationary phases are represented by the formula of structure (I), containing at least one asymmetric carbon atom, and a substituent acting as a spacer. The stationary phases of the present invention are useful in the preparation of chromatographic columns useful for the separation of enantiomers.

Chiral stationary phases for enantiomers separation and their preparation

A method for manufacturing S-3-(4'-tert-butyl)-phenyl-2-methyl propylamines having the structure I ##STR1## where NR.sub.1 R.sub.2 is a dialkylamine group, pyrrolidine, piperidine, or cis-3,5-dimethyl morpholine, comprising a reduction of the compound having the structure II ##STR2##

Method for the enantioselective synthesis of chiral derivatives of S-3-(4'-

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Zagreb, Croatia

Vitomir Sunjic