Bracco Imaging S.p.a.

Vito Lorusso

Fulvio Uggeri

Rolf E Swenson

Kondareddiar Ramalingam

Luciano Lattuada

Edmund R Marinelli

Silvio Aime

Bo Song

Pierfrancesco Morosini

Linda Chaabane

The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel peptides able to bind fibrin, to a process for their preparation and to compositions thereof for use in therapy and diagnostics. The compounds of the invention bind, in particular, to fibrin present in the extracellular matrix (EC) of tumor or connective tissue of stroma thus acting as targeting moieties able to bring and successfully bound an active moiety linked thereto to fibrin depositions inside solid tumors.

Fibrin binding peptide conjugates for diagnostic and therapeutic applications

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Bussero, Italy

Vito Lorusso