Ajinomoto Co., Ltd.

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Vitaly Arkadievich Livshits

Evgeny Moiseevich Khurges

Mikhail Markovich Gusyatiner

Tatyana Alexandrovna Bachina

Nelli Isaakovna Zhdanova

Nikolai Kazimirovich Yankovsky

Alexandr Konstantinovich Sokolov

Vladimir Georgievich Debabov

Jury I Kozlov

Albert Fedorovich Sholin

Raisa Alexandrovna Arsatiants

Alla Valentinovna Belareva

Jury Dmitrievich Tsygankov

Tatyana Grigorievna Plotnikova

Tamara Mikhailovna Pozdnyakova

Andrei Jurievich Chistoserdov

Vladimir G Debabov

Irina Olegovna Shakalis

Irina Clegovna Shakalis

Rustem Saidovich Shakulov

Natalia Pavlovna Zakataeva

Ekaterina Aleksandrovna Kutukova

Zakataeva Natalya Pavlovva

Aaveilova Oksaua Fedorovva

Natalya Pavlovna Zakataeva

Vladimir Venyamiovich Aleoshin

Alla Valentinovna Balareova

Irina Lvovna Tokhmakova

Jury Ivancvich Kozlov

Yury Ivanovich Kozlov

Sergei Vladimirovich Mashko

Andrei J Chistoserdov

Ljudmila F Kozyreva

Sergey Viktorovich Gronsky

Tamara Mikhailcvna Pozdnyakova

Nelli Isaakcvna Zhdanova

Anna Evgenievna Novikova

Mikhail N Rozinov

Boris A Rebentish

Vera N Moshentseva

Viktor P Antipov

Evgeny Mciseevich Khurges

Andrei Jurievich Christoserdov

Methods for producing purine nucleosides, and purine nucleotides, such as inosine and 5'-inosinic acid are provided which include using a bacterium belonging to the genusor to the genuswherein the purine nucleoside productivity of said bacterium is enhanced by increasing an activity of the YdhL protein. Also disclosed is the amino acid sequence of the YdhL protein fromand the gene encoding it.

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A method is provided for producing a purine nucleoside, such as inosine and guanosine, and a method for producing a 5'-purine nucleotide such as 5&#x2032;-inosinic acid or 5&#x2032;-guanylic acid, using a bacterium belonging to the either genusor genus, wherein purine nucleoside productivity of said bacterium is enhanced by enhancing an activity of a protein encoded by the yeaS (leuE) gene.

A bacterial strain ofis described which produces L-threonine, and is obtained by a process comprising transduction by bacteriophage P1 which bears a transposon which inactivates threonine dehydrogenase activity, and isolation of a transductant lacking threonine dehydrogenase activity.

A bacterium which has an ability to produce an amino acid and in which a novel gene (rhtB) coding for a protein having an activity of making a bacterium having the protein L-homoserine-resistant is enhanced, is cultivated in a culture medium to produce and accumulate the amino acid in the medium, and the amino acid is recovered from the medium.

DNA coding for protein which confers on bacterium Escherichia coli resistance to L-homoserine, and method for producing L-amino acids

The present invention provides a method for deriving an strain which produces L-theronine from strain VNIIgenetika 472T23 by transducing with bacteriophage P1 which bears a transposon.

Bacterial strain of Escherichia coli BKIIM B-3996 as the producer of L-threonine

DNA coding for protein which confers on bacterium escherichia coli resistance to L-homoserine and method for producing L-amino acids

strains derived form,strain VNIIgenetika 472t23 and obtained by a process involving transduction by bacteriophage P1 which bears a transposon which inactivates threonine dehydrogenase activity and isolation of a transductant lacking threonine dehydrogenase activity are useful for producing L-threonine.

Escherichia coli strain and method for producing L-threonine

A bacterial strain of Escherichia coli BKIIM B-3996, a producer of L-threonine, containing a recombinant plasmid pVIC40 and deposited on Nov. 19, 1987 in the collection of microorganism cultures at the USSR Antiobiotics Research Institute under Reg. No. 1867.

Bacterial strain of Escherichia coli BKIIM B-3996 as the producer of

A bacterial strain of Escherichia coli BKIIM B-3996, a producer of L-threonine, containing a recombinant plasmid pVIC40 and deposited on Nov. 19, 1987 in the collection of microorganism cultures at the USSR Antibiotics Research Institute under Reg. No. 1867.

Bacterial strain of escherichia coli BKIIM B-3996 as the producer of

A method for constructing microorganism strains which produce amino acids comprising: combining in one bacterial genome (a) a mutation affecting the aminoacyl-tRNA synthetase corresponding to the selected amino acid, conferring cells auxotrophy which cannot be fully suppressed by addition of usual concentration this amino acid into the culture medium and (b) a mutation which destroys the negative regulation of selected amino acid biosynthesis to yield a strain capable of increased production of the selected amino acid. Strains producing isoleucine and valine. Methods to produce isoleucine and valine by culturing those strains.

Strains of Escherichia coli which produce isoleucine or valine and a

A bacterial strain of Escherichia coli VNII genetika 472T23, a producer of L-threonine, containing the plasmid PYN7 and a plasmid-free variant of E. coli; strain VNII genetika 472T23, deposited at the American Type Culture Collection under Accesion No. ATCC 98081 and 98082, respectively.

Bacterial strain of Escherichia coli VNII genetika 472T23 as the

The present invention provides strains of Escherichia coli which have an isoleucine-tRNA synthetase with an increased Km and no negative feedback inhibition of isoleucine production. These strains are effective for the production of isoleucine in high amounts.

Production of isoleucine by escherichia coli having isoleucine

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Moscow, Russia

Vitaly Arkadievich Livshits