Massachusetts Institute of Technology

Viswanathan Sasisekharan

Ram Sasisekharan

S Raguram

Venkataramanan Soundararajan

Vidya Subramanian

Karthik Viswanathan

Kannan Tharakaraman

Robert Samuel Langer

Ganesh Venkataraman

Rahul Raman

Charles L Cooney

Aarthi Chandrasekaran

Aravind Srinivasan

Sasi Raguram

Ratnaleela Bobba

The present invention provides antibodies (e.g., monoclonal antibodies, human antibodies, humanized antibodies, etc.), which bind to multiple influenza strains. Such antibodies are useful, for example, in the prophylaxis, treatment, diagnosis, and/or study of influenza.

Agents for influenza neutralization

The present invention provides novel agents for broad spectrum influenza neutralization. The present invention provides agents for inhibiting influenza infection by bind to the influenza virus and/or hemagglutinin (HA) polypeptides and/or HA receptors, and reagents and methods relating thereto. The present invention provides a system for analyzing interactions between infolds and the interaction partners that bind to them.

Engineered polypeptide agents for targeted broad spectrum influenza neutralization

The present invention provides umbrella-topology glycan decoys. The present invention provides systems and methods treating influenza infection utilizing inventive umbrella-topology glycan decoys. The present invention provides methods for identifying novel umbrella-topology glycan decoys.

Decoy influenza therapies

A computer-implemented process determines candidate three-dimensional shapes of ring-shaped molecules through an exhaustive search of combinations of torsion angles of the bonds of the ring, given known bond lengths and bond angles for the bonds between atoms of the rings, a range of torsion angles and a resolution. Candidate combinations of the torsion angles are selected according to the range and resolution and coordinates of the atoms of the ring are determined for each candidate combination. It is then determined whether each candidate combination defines a physically possible ring. Indications of such candidate combinations are recorded. Candidate combination may then be selected from those recorded so that coordinates of atoms in candidate repetitive structures may be determined.

Computer-implemented process and computer system for estimating the

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Cambridge, MA, United States of America

Viswanathan Sasisekharan