Merck Sharp + Dohme Corp.

Zendrive, Inc.

Southern Research Institute

Vishal Verma

F George Njoroge

Jonathan Arie Matus

Pankaj Risbood

Jayanta Pal

Ashok Arasappan

Vinay M Girijavallabhan

Romit Roy Choudhury

Bipul Islam

Frank W Bennett

Qun Dang

Stephane L Bogen

David Brian Olsen

Andrew William Stamford

Joseph P Vacca

Ian W Davies

Dmitri A Pissarnitski

Angela Dawn Kerekes

Srikanth Venkatraman

John A Secrist, Iii

Ying Huang

Subramaniam Ananthan

Latha G Nair

Francisco Velazquez

Joseph A Maddry

Yuhua Huang

Robert C Reynolds

Hollis S Kezar, Iii

Cecil D Kwong

Anita T Fowler

Abhijit Roychowdhury

Neng-Yang Shih

Joseph A Kozlowski

John J Piwinski

Ling Tong

Malcolm Maccoss

Kevin X Chen

Bandarpalle B Shankar

Seong Heon Kim

Feng Geng

Jeremy Clark

Regina Huelgas

Kevin Chen

Shivam Singh

Vinay Girjavallabhan

Dimitri Pissarnitski

Dimitri Pissarnitzki

A method and system for detecting an accident of a vehicle, the method including: receiving a movement dataset collected at least at one of a location sensor and a motion sensor arranged within the vehicle, during a time period of movement of the vehicle, extracting a set of movement features associated with at least one of a position, a velocity, and an acceleration characterizing the movement of the vehicle during the time period, detecting a vehicular accident event from processing the set of movement features with an accident detection model, and in response to detecting the vehicular accident event, automatically initiating an accident response action.

Method for smartphone-based accident detection

A method for risk determination of a route includes collecting a set of inputs and determining a set of risk scores. Additionally, the method can include any or all of: processing the set of inputs; organizing the set of inputs; determining a model based on the set of inputs; determining a set of risk scores; producing an outputs based on the set of risk scores; and/or any other suitable processes.

Method and system for risk determination of a route

The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein each of R, R, X, Y, Z, R, R, R, R, R, R, R, R, R, Rand n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders. 

Substituted pyridine and pyrimidine derivatives and their use in treating viral infections

The present invention relates to 5'-Substituted Nucleoside Derivatives of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein X, Y, Z, R, Rand Rare as defined herein and B is a 7-deaza-9-purinyl moiety. The present invention also relates to compositions comprising at least one 5&#x2032;-Substituted Nucleoside Derivative, and methods of using the 5&#x2032;-Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient. 

5'-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases

The present invention relates to 5'-Substituted Nucleoside Analogs of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, Z, R, R, Rand Rare as defined herein. The present invention also relates to compositions comprising at least one 5&#x2032;-Substituted Nucleoside Analog, and methods of using the 5&#x2032;-Substituted Nucleoside Analogs for treating or preventing HCV infection in a patient. 

5'-substituted nucleoside analogs and methods of use thereof for the treatment of viral diseases

The present invention relates to 2'-Azido Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R, Rand Rare as defined herein. The present invention also relates to compositions comprising at least one 2&#x2032;-Azido Substituted Nucleoside Derivative, and methods of using the 2&#x2032;-Azido Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient. 

2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases

The present invention relates to 2'-Cyano Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R, Rand Rare as defined herein. The present invention also relates to compositions comprising at least one 2&#x2032;-Cyano Substituted Nucleoside Derivative, and methods of using the 2&#x2032;-Cyano Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient. 

2'-cyano substituted nucleoside derivatives and methods of use thereof useful for the treatment of viral diseases

The present invention relates to 2'-Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, X, R, Rand Rare as defined herein. The present invention also relates to compositions comprising at least one 2&#x2032;-Substituted Nucleoside Derivative, and methods of using the 2&#x2032;-Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient. 

2'-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases

Growing community of inventors

San Francisco, CA, United States of America

Vishal Verma