Council of Scientific and Industrial Research

Vishal Singh

Anil Kumar

Girish Kumar Jain

Anil Kumar Dwivedi

Madhu Dikshit

Prem Prakash

Varsha Gupta

Manish Jain

Vivek Khanna

Ankita Misra

Manoj Kumar Barthwal

Rabi Sankar Bhatta

Tanveer Irshad Siddiqui

Dinesh Kumar Dikshit

Chirag Shah

Saurabh Patil

Mridul Babbar

Lakshay Dang

Method and system to ascertain location of drone box () for stabilized landing and charging of drones (), comprising a plurality of drones () and at least a drone box () having a passive sensing circuit () detecting a touchdown signal of all the ground interface () of the drone (--) at a plurality of sensor zones () for a minimum prescribed time, a detection of any missing touch down signal for the minimum prescribed time due to an inappropriate landing preventing next take off of the drone (--), the passive sensing circuit () prevents activation of any sensor zone () till all the ground interfaces () are detected as touched down, the sensor zones () differentiates between presence of the ground interface () and any other presence including human touch, animal touch, foreign matter and or contamination and a combination thereof.

Method and system to ascertain location of drone box for stabilized landing and charging of drones

Chiral 1-(4-methylphenylmethyl)-5-oxo-{N-[(3-t-butoxycarbonyl-aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamides as inhibitors of collagen induced platelet activation and adhesion. The present invention provides chiral (2S)-1-(4-methylphenylmethyl)-5-oxo-(3S)-{N-[(3-t-butoxycarbonyl aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamide, and (2S)-1-(4-methylphenylmethyl)-5-oxo-(3R)-{N-[(3-t-butoxycarbonyl amino methyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamide of formula 6 and 7 respectively. The present invention also relates to use of these moieties as inhibitors of collagen induced platelet adhesion and aggregation mediated through collagen receptors. The present invention provides a process for preparation of chiral carboxamides of formula 6 and 7 using the process which has advantage to avoid any racemization at the a-carboxylic center, during N-alkylation. The reagent LiHMDS is used at low temperatures to furnish methyl N-(p-methylphenylmethyl)1pyroglutamate in good chiral purity. 

Chiral 1-(4-methylphenylmethyl)-5-oxo-{N-[(3-t-butoxycarbonyl-aminomethyl)]-piperidin-1-yl)-pyrrolidine as inhibitors of collagen induced platelet activation and adhesion

Chiral 1-(4-methylphenylmethyl)-5-oxo-{N-[(3-t-butoxycarbonyl-aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamides as inhibitors of collagen induced platelet activation and adhesion The present invention provides chiral (2S)-1-(4-methyl-phenylmethyl)-5-oxo-(3S)&#x2014;{N-[(3-t-butoxycarbonyl aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamide, and (2S)-1-(4-methylphenylmethyl)-5-oxo-(3R)&#x2014;{N-[(3-t-butoxycarbonyl amino methyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamide of formula 6 and 7 respectively. The present invention also relates to use of these moieties as inhibitors of collagen induced platelet adhesion and aggregation mediated through collagen receptors. The present invention provides a process for preparation of chiral carboxamides of formula 6 and 7 using the process which has advantage to avoid any racemization at the a-carboxylic center, during N-alkylation. The reagent LiHMDS is used at low temperatures to furnish methyl N-(p methylphenylmethyl)lpyroglutamate in good chiral purity. 

Chiral 1-(4-methylphenylmethyl)-5-OXO-{N-[3-T-butoxycarbonyl-aminomethyl)]-piperidin-1-yl-pyrrolidine-2-carboxamides as inhibitors of collagen induced platelet activation and adhesion

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Lucknow, India

Vishal Singh