University of Massachusetts

US Government As Represented by the Secretary of the Army

Massachusetts Institute of Technology

Virinder Singh Parmar

Lynne Ann Samuelson

Jayant Kumar

Ashok L Cholli

Ferdinando F Bruno

Vijayendra Kumar

Rajesh Kumar

Arthur C Watterson

Javant Kumar

Ashish Dhawan

Clark K Colton

Ravi Mosurkal

Robert Joseph Fisher

Vincent B Tucci

A polymer is characterized by a repeat unit represented by Structural Formula (I): or a copolymer thereof. A crosslinked polymer characterized by a repeat unit represented by Structural Formula (II), (III), (IV) or (V): or a copolymer thereof, wherein at least one such repeat unit of a first polymer strand is crosslinked with at least one repeat unit of a second polymer strand by at least one bridging unit, the first and second polymer strands and the repeat unit being components of the crosslinked polymer.

Mixed organic and inorganic polymers

The present invention relates to amphiphilic polymers, and micelles and compositions comprising the same, and their use in a variety of biological settings, including imaging, targeting drugs, or a combination thereof for diagnostic and therapeutic purposes.

Amphiphilic polymers and methods of use thereof

Antioxidant polymers of the present invention comprise repeat units that include one or both of Structural Formulas (I) and (II): wherein: The invention also includes methods of using and preparing these polymers.

Polymeric antioxidants

The following is an examiner's statement of reasons for allowance: an antioxidant polymer and method of preparing, the antioxidant comprising repeat units that include one or both of Structural Formulas (I) and (II) wherein R is &#x2014;H or a substituted or unsubstituted alkyl, acyl or aryl group; Ring A is substituted with at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group; Ring B is substituted with at least one &#x2014;H and at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group is not taught nor fairly suggested by the prior art or any combination thereof.

A method of preparing a phenolic polymer comprising: a) protecting at least one hydroxyl group of a substituted or unsubstituted phenol represented by Structural Formula (XXIX), wherein: R, R, R, Rand Rare independently &#x2014;H, &#x2014;OH, &#x2014;NH, &#x2014;SH, a substituted or unsubstituted alkyl or aryl group, a substituted or unsubstituted alkoxycarbonyl or aryloxycarbonyl group, a substituted or unsubstituted alkoxy group or a saturated or unsaturated carboxylic acid group; or R, R, R, Ror R, in conjunction with an adjacent R, R, R, Ror R, forms a substituted or unsubstituted alkylene dioxy group; provided that at least one of R, R, R, Ror Ris a tert-butyl group-ethenyl--carboxylic acid or ester thereof, a substituted or unsubstituted alkylene dioxy group or a substituted or unsubstituted n-alkoxycarbonyl group, at least one of R, R, R, Ror Ris a hydroxyl group, and at least one of R, R, R, Rand Ris &#x2014;H; with a protecting group, wherein thereby obtaining one or more protected hydroxyl groups; and b) polymerizing the substituted or unsubstituted phenol, thereby obtaining the phenolic polymer.

Antioxidant polymers of the present invention comprise repeat units that include one or both of Structural Formulas (I) and (II): wherein:

The invention relates to new methods of enzymatic synthesis of polymers such as polyorganosilicones and polyesters, and new polymers made by these methods.

Growing community of inventors

Lowell, MA, United States of America

Virinder Singh Parmar