Other

Wisconsin Alumni Research Foundation

University of California

Virginia E Kincaid

Laura Lee Kiessling

Brian K Shoichet

Nir London

Hui Wang

Wenhui Zhou

Melanie Dart

Nidhi Nath

Rod Flemming

Becky Godat

Provided herein are sulfo n-hydroxysuccimidyl ester (sulfo-SE) linked peptides, methods of synthesis thereof, and methods of using such peptides for labeling of biomolecules. In particular, peptides comprising non-alkyl group such as serine, threonine, cysteine, tyrosine, glutamic acid, and aspartic acid are stably modified (e.g., without autoreactivity) with a sulfo-SE group and used to label or otherwise modify biomolecules.

Reactive peptide labeling

Compounds and salts thereof which inhibit microbial growth or attenuate the virulence of pathogenic microorganisms and which inhibit UDP-galactopyranose mutase (UGM). Compounds of the invention include triazolothiadiazines, particularly 3, 6, 7-substituted-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines, and 4-(1H-pyrrol-3-yl) thiazoles, particularly 4-(1,2,5-substituted-1H-pyrrol-3-yl)-2-substituted thiazoles, and salts thereof. Methods for inhibiting growth or attenuating virulence of microbial pathogens including mycobacterium, for example,andand, for example,. Methods for inhibiting eukaryotic human and animal pathogens, and fungi and nematodes in particular. Methods for treatment of infections by prokaryotic and eukaryotic pathogens employing compounds of the invention.

Inhibitors of UDP-galactopyranose mutase

Compounds and salts thereof which inhibit microbial growth or attenuate the virulence of pathogenic microorganisms and which inhibit UDP-galactopyranose mutase (UGM). Compounds of the invention include triazolothiadiazines, particularly 3,6,7-substituted-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines, and 4-(1H-pyrrol-3-yl) thiazoles, particularly 4-(1,2,5-substituted-1H-pyrrol-3-yl)-2-substituted thiazoles, and salts thereof. Methods for inhibiting growth or attenuating virulence of microbial pathogens including mycobacterium, for example,andand, for example,. Methods for inhibiting eukaryotic human and animal pathogens, and fungi and nematodes in particular. Methods for treatment of infections by prokaryotic and eukaryotic pathogens employing compounds of the invention.

An apparatus for animal litter called a Cat Litter Pod. This apparatus features a bottom built-in liner, impervious to liquids; a top gauze-like, cheesecloth material to cover the litter granules; a way to join the top and bottom to provide an encasement space; and absorbent granules of various litter material inside the encasement. This litter pod provides convenience and portability to necessary sanitation devices for cats that are kept inside. Configured as a low profile and disposable this apparatus is particularly important to older or infirm cats that have problems with limited mobility.

Cat litter pods

Growing community of inventors

Muncie, IN, United States of America

Virginia E Kincaid