The Charles Stark Draper Laboratory, Inc.

Johnson & Johnson Innovation LLC

Violet G Finley

Joseph L Charest

Jeffrey T Borenstein

Christopher M DiBiasio

Jose A Santos

Chris DiBiasio

The present disclosure describes a device and method to clear solutes from a patient's blood while maintaining fluid balance. In some implementations, the device and method is used to assist the filtration functions of a patient's liver or kidney. The device includes a plurality of hollow fibers that pass through a sequence of alternating filtration chambers and infusion chambers. The filtration chambers filter the patient's blood while the infusion chambers rehydrate the filtered blood.

Hemotransfiltration hollow fiber device

The general disclosure discusses a system and method for improving the efficacy of blood filtration treatments such as hemodialysis, hemofiltration, and hemodiafiltration. More particularly, the disclosure discusses a microfluidic device that includes first and second channels separated by a permeable membrane. One of the channels is configured for blood flow and includes a protein gel disruption layer. The protein gel disruption layer includes a plurality of elements at least partially extending across the blood flow channel that reduce the formation of a boundary layer or gel layer at the blood-membrane interface.

Microfluidic organ assist device incorporating boundary layer disrupters

Growing community of inventors

Medford, MA, United States of America

Violet G Finley