The Cleveland Clinic Foundation

University of Nebraska

University of Michigan

The United States of America, As Represented by the Secretary, Department of Health and Human Services

National Institutes of Health (nih)

Protransit Nanotherapy, LLC

Vinod D Labhasetwar

Maram K Reddy

Robert J Levy

Jaspreet K Vasir

Sivakumar Vijayaraghavalu

Hagit Cohen

Steven A Goldstein

Jeffrey F Bonadio

Sanjeeb Kumar Sahoo

Hayder H Jaffer

Isaac M Adjei

Sanjeeb K Sahoo

The invention is directed to a method of treating a spinal cord injury, a neurodegenerative disease or a neuronal injury in an individual in need thereof comprising administering an effective amount of superoxide dismutase (SOD) and catalase to the individual, wherein the superoxide dismutase and the catalase are encapsulated in one or more nanoparticles that release the SOD and catalase upon administration. Another aspect of the invention is directed to compositions comprising superoxide dismutase (SOD) and catalase encapsulated in one or more nanoparticles.

Methods of treating spinal cord injury

Provided herein are compositions, systems, kits, and methods for treating cancer in at least one bone of a subject using nanoparticles encapsulating, or conjugated to, an anti-cancer agent. In other embodiments, provided herein are composition, systems, kits, and methods for treating a bone disease (e.g., osteoporosis) in a subject using nanoparticle encapsulating, or conjugated to, a RANKL inhibitor. The nanoparticle are, in certain embodiments, neutral or nearly neutral in charge (e.g., zeta potential between &#x2212;5 and +5 mV) and less than 250 nm in diameter on average (e.g. have an average diameter between 100 and 200 nm).

Nanoparticles for drug delivery to treat bone disease

Provided herein are methods of inhibiting proliferation of one or more tumor cells comprising contacting the one or more tumor cells with a composition comprising one or more epigenetic drugs that inhibit one or more epigenetic mechanisms of the tumor cells, wherein the one or more epigenetic drugs are encapsulated in a nanogel. The invention is also directed to methods of treating a tumor, metastasis of a tumor or a combination thereof in an individual in need thereof. The invention is also directed to a method of sequentially delivering one or more epigenetic drugs that alter one or more epigenetic mechanisms of a tumor cell and one or more chemotherapeutic drugs to an individual that has a tumor. Compositions which comprise one or more epigenetic drugs that alter one or more epigenetic mechanisms of a tumor cell, wherein the one or more epigenetic drugs are encapsulated in a nanogel.

Nanogel-mediated drug delivery

Compositions and methods for the treatment of skin disorders or disease are provided.

Compositions and methods for the treatment of photoaging and other conditions

A sustained-release composition for stimulating endothelial cell growth including a nitric oxide synthase within a nanoparticle comprising a biocompatible polymer is described. The sustained-release composition can be administered as part of a pharmaceutical composition, or can be coated on a medical device. The nitric oxide synthase-containing nanoparticles can be used in a method of inducing endothelium formation in a blood vessel.

Nitric oxide synthase nanoparticles for treatment of vascular disease

The present invention is a composition composed of a therapeutic agent encapsulated in a copolymer of an N-alkylacrylamide, a vinyl monomer, and a polyethylene glycol (PEG) conjugate and a method for using the same in the treatment or prevention of a disease or condition.

Sustained-release nanoparticle compositions and methods using the same

Surface-modified polymeric nanoparticles (NPs), compositions for making them, and their use in drug delivery are disclosed.

Surface-modified nanoparticles for intracellular delivery of therapeutic agents and composition for making same

Protein containing nanoparticles and methods of use thereof for the treatment of proliferative disorders are disclosed.

Apoptosis-modulating p53 protein therapy for vascular disorders and nanoparticles containing the same

The present invention relates to a method for inhibiting reperfusion injury in the brain. The method involve injecting via the carotid artery or jugular vein an antioxidant-loaded nanoparticle. A nanoparticle formulation containing an inert plasticizer is also provided for sustained release of an active agent.

Method for inhibiting reperfusion injury in the brain

Sustained-release nanoparticle compositions and methods for using the same

Method and composition for inhibiting reperfusion injury in the brain

The present invention relates to novel compositions comprising microspheres and/or nanospheres containing condensed polyanionic bioactive agents, such as DNA. The polyanionic bioactive agent in the microspheres and/or nanospheres is preferably condensed using a polycationic condensing agent, such as poly-L-lysine. The present invention further relates to methods for producing the microspheres and/or nanospheres containing condensed polyanionic bioactive agents.

Microspheres containing condensed polyanionic bioactive agents and methods for their production

The invention describes improved methods for incorporating nucleic acids into polymeric microspheres and/or nanospheres through the use of a condensing agent.

Compositions and methods for coating medical devices with pharmaceutical agents and devices coated with the compositions. The coated devices provide controlled or sustained release of pharmaceutical agents for the treatment of wounds or disease.

Growing community of inventors

Omaha, NE, United States of America

Vinod D Labhasetwar