Allergan, Inc.

Allergen, Inc.

Vinh X Ngo

David W Old

Todd S Gac

Mark Holoboski

Mari F Posner

Robert M Burk

Wha Bin Im

Wha-Bin Im

Disclosed herein are compounds having formula (I) wherein a dashed line represents the presence or adsence of a bond; Y is an organic acid functional group, or an amide or ester thereof; or Y is hydroxymethyl or an ester thereof; or Y is a tetrazolyl functional group; A is &#x2014;(CH)&#x2014;, cis &#x2014;CHCH&#x2550;CH&#x2014;(CH)&#x2014;, or &#x2014;CHC&#x2550;C&#x2014;(CH)&#x2014;, wherein 1 or 2 carbon atoms may be replaced by S or O; or A is &#x2014;(CH)&#x2014;Ar&#x2014;(CH)&#x2014;, wherein Ar is interarylene or heterointerarylene, the sum of m and o is 1, 2, 3, or 4, and wherein 1 &#x2014;CH&#x2014; may be replaced by S or O, and 1 &#x2014;CH&#x2014;CH&#x2014; may be replaced by &#x2014;CH&#x2550;CH&#x2014; or &#x2014;C&#x2261;C&#x2014;; Uand Uare independently selected from &#x2014;H, &#x2550;O, &#x2014;OH, &#x2014;F, &#x2014;Cl, and &#x2014;CN; and B is aryl or heteroaryl, for use as acular hypotensive agent.

Therapeutic substituted cyclopentanes

Disclosed herein are compounds having the formula (I) wherein a dashed line represents the presence or absence of a bond; Y is an organic acid functional group, or an amide or ester thereof; or Y is hydroxymethyl or an ether thereof; or Y is a tetrazolyl functional group; A is &#x2014;(CH)&#x2014;, cis &#x2014;CHCH&#x2550;CH&#x2014;(CH)&#x2014;, or &#x2014;CHC&#x2550;C&#x2014;(CH)&#x2014;, wherein 1 or 2 carbon atoms may be replaced by S or O; or A is &#x2014;(CH)&#x2014;Ar&#x2014;(CH)&#x2014; wherein Ar is interarylene or heterointerarylene, the sum of m and o is 1, 2, 3, or 4, and wherein 1 &#x2014;CH&#x2014; may be replaced by S or O, and 1 &#x2014;CH&#x2014;CH&#x2014; may be replaced by &#x2014;CH&#x2550;CH&#x2014; or &#x2014;C&#x2261;C&#x2014;; Uand Uare independently selected from &#x2014;H, &#x2550;O, &#x2014;OH, &#x2014;F, &#x2014;Cl, and &#x2014;CN; and B is aryl or heteroaryl, for use as acular hypotensive agent. 

The invention provides compositions and methods for reducing healing wounds and reducing scars and blemishes. The compositions and methods of the invention include at least one EP4 agonist set forth herein. Wounds and or scars that can be treated by the compositions and methods of the invention can arise from events such as surgery, trauma, disease, mechanical injury, burn, radiation, poisoning, and the like.

15-aryl prostaglandins as EP4 agonists, and methods of use thereof

Compounds such as those represented by Formulas 1-6 can be used in topical liquids, creams, or other dosage forms such as solids, for reducing intraocular pressure, treating glaucoma, growing hair, or other medical uses.

Secondary amines as therapeutic agents

Compounds comprising formula (I) or a pharmaceutically acceptable salt thereof, a dashed line represent the presence or absence of a double bond, are disclosed, wherein J, J, U, B, Y, and A are as described in claims-. Methods, compositions, and medicaments related thereto are also disclosed, for treating glaucoma, inflammatory bowel disease and baldness. 

Therapeutic compounds

Therapeutic compounds, methods, and compositions are disclosed herein for treating glaucoma and baldness in mammals. The specific compounds are described herein and are modified prostaglandin derivates.

Substituted cyclopentanes or cyclopentanones as therapeutic agents

Therapeutic compounds, compositions, methods, and medicaments related thereto are disclosed herein.

Therapeutic substituted lactams

Disclosed herein are compounds of the formula or salts or bioisosteres thereof. Therapeutic methods, medicaments, and compositions related thereto are also disclosed.

Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof are disclosed, wherein a dashed line represents the presence or absence of a bond; and, wherein Y, A, R, D, and n are as described. Methods, compositions, and medicaments related thereto are also disclosed. 

Disclosed herein is a compound of the formula. Therapeutic methods, compositions, and medicaments for the treatment of glaucoma or ocular hypertension related thereto are also disclosed. 

Disclosed herein are compounds of the formula therapeutic methods, compositions, and medicaments related thereto are also disclosed.

Disclosed herein are compounds having a formula: (I) Compositions, methods, and medicaments related thereto are also disclosed. 

Compounds comprising Formula (I) or a pharmaceutically acceptable salt thereof, are disclosed, wherein J, J, U, B, Y, and A are as described. Methods, compositions, and medicaments related thereto are also disclosed, for treating glaucoma, inflammatory bowel disease and baldness. 

Disclosed herein is a compound having a formula therapeutic methods, compositions, and medicaments related thereto are also disclosed.

Therapeutic substituted chlorocyclopentanols

Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof,are disclosed, wherein G, B, Y, and A are as described. Methods, compositions, and medicaments related thereto are also disclosed.

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Huntington Beach, CA, United States of America

Vinh X Ngo