Tata Consultancy Services Limited

Vinesh Balakrishnan Yezhuvath

Venkataramana Runkana

Venkata Sudheendra Buddhiraju

Vishnu Swaroopji Masampally

Anurag Singh Rathore

Anamika Tiwari

Amey Ahsok Kulkarni

Nikita Saxena

Garima Thakur

Shantanu Banerjee

Keshari Nandan Gupta

Anshul Agarwal

Navnath Manohar Deore

Process control of continuous production of biomolecules is a major challenge due to complex nature of processes and time scales of operations involved. Availability of key process variables in real-time is one of main requirements. This disclosure relates to a processor implemented method of controlling a continuous bioprocessing plant which includes at least one of: receiving, an input data associated with one or more equipments; generating, by a recipe builder, a sequence of unit operations to determine at least one job order based on the at least input data; obtaining, a control decision associated with a control parameter based on the at least one job order; communicating, via the middleware, the control decision associated with the control parameter to the PLC; and executing, by a control system of the PLC, the control decision on a unit equipment to control: (i) a continuous bioprocessing train, and (ii) an individual unit operation.

Method and system to control a continuous bioprocessing

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Noida, India

Vinesh Balakrishnan Yezhuvath