Janssen Biotech, Inc.

National Institutes of Health, a Component of the US Dept. of Health & Human Services

Vineet Kumar

Richard Jansson

Jane B Neckers

Yeong Sang Kim

Sunmin Lee

Sanjay V Malhotra

The present invention relates to subcutaneous formulations of anti-CD38 antibodies and their uses.

Subcutaneous formulations of anti-CD38 antibodies and their uses

Disclosed are compounds which are nuclear receptor modulators that can act as antagonists to the androgen receptor, for example, a compound of Formula I: wherein Rto Rand Xto Xare as described herein, as well as pharmaceutically acceptable salts, solvates, and stereoisomers thereof. Pharmaceutical compositions comprising such compounds, as well as methods of use, and treatment for cancers, including prostate cancers, other nuclear receptor mediated cancers, and other conditions, are also disclosed.

Nuclear receptor modulators and their use for the treatment and prevention of cancer

Disclosed are compounds which are nuclear receptor modulators that can act as antagonists to the androgen receptor, for example, a compound of Formula I: wherein Rto Rand Xto Xare as described herein, as well as pharmaceutically acceptable salts, solvates, and stereoisomers thereof. Pharmaceutical compositions comprising such compounds, as well as methods of use, and treatment for cancers, including prostate cancers, other nuclear receptor mediated cancers, and other conditions, are also disclosed. 

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Spring House, PA, United States of America

Vineet Kumar