Ludwig Institute for Cancer Research Limited

Oxford University Innovation Limited

The University of Birmingham

The Chancellor, Masters and Scholars of the University of Oxford

Blink Therapeutics Limited

Vincenzo Cerundolo

Gurdyal S Besra

Liam R Cox

Gerd J Ritter

Richard R Schmidt

Gopal Reddy

Rengarajan Balamurugan

Mariolina Salio

Jonathan Silk

Lloyd J Old

Sacha Gnjatic

Djordje Atanackovic

Rodney Dunbar

Ji-li Chen

Khoon-Lin Ling

Simon Eastman

Julia Eckl-Dorna

Patricia Barral

Facundo Batista

Gurdyal Besra

Cox Liam

Disclosed herein are &#x3b1;-galactosylceramide (&#x3b1;-GalCer) analogs and compositions thereof, methods of activating invariant Natural Killer T (iNKT) cells using said analogs, methods of treating diseases by activating iNKT cells using said analogs, and combination therapy of said analogs.

iNKT cell modulators and methods of using the same

The invention provides liposomes containing nonglycosidic ceramides within their bilayers, and compositions thereof. These liposomes activate murine iNKT cells and induce dendritic cell (DC) maturation, both in vitro and in vivo at an efficacy that is comparable to their corresponding soluble nonglycosidic ceramides. Also provided are methods for treating diseases using the liposomes and compositions of the invention.

Liposomal formulation of nonglycosidic ceramides and uses thereof

Analogs of alpha galactosylceramide and uses thereof

There are disclosed compound of formula I, in which Rrepresents a hydrophobic moiety adapted to occupy the C' channel of human CDId, Rrepresents a hydrophobic moiety adapted to occupy the A&#x2032; channel of human CDId, such that Rfills at least at least 30% of the occupied volume of the C&#x2032; channel compared to the volume occupied by the terminal nCHof the sphingosine chain of &#x3b1;-galactosylceramide when bound to human CDId and Rfills at least 30% of the occupied volume of the A&#x2032; channel compared to the volume occupied by the terminal nCHof the acyl chain of &#x3b1;-galactosylceramide when bound to human CDId Rrepresents hydrogen or OH, Rand Reach represent hydrogen and in addition, when Rrepresents hydrogen, Rand Rtogether may form a single bond, X represents or &#x2014;CHA(CHOH)Y or &#x2014;P(=0)(0)0CH(CH0H)Y, in which Y represents CHBB, n represents an integer from 1 to 4, m represents 0 or 1, A &#xe5;represents hydrogen, one of Band Brepresents H, OH or phenyl, and the other represents hydrogen or one of Band Brepresents hydroxyl and the other represents phenyl, in addition, when n represents 4, then A together with one of Band Btogether forms a single bond and the other of Band Brepresents H, OH or OSOH and pharmaceutically acceptable salts thereof; the compounds of formula I are indicted for use in the treatment of a virus, microbial infection, parasite, an autoimmune disease, cancer, allergy or asthma. 

Analogs of alpha galactosyceramide and uses thereof

The invention provides methods, compositions and kits for inducing and/or enhancing an immune response in a subject. The invention in some aspects includes polypeptide and nucleic acid molecules that induce and/or enhance an immune response. In some aspects of the invention, the polypeptide and/or nucleic acid molecules of the invention are useful to induce and/or enhance an immune response in a subject who has or is suspected of having cancer.

Method for inducing immune response to NY-CO-58

The invention relates to variant peptides which bind to HLA molecules, leading to lysis of cells via cytolytic T cell lines. The variants are based upon NY-ESO-1 peptides. The peptides can be incorporated into immune tetramers, which are useful as T cell sorters.

NY-ESO-1 peptide derivatives, and uses thereof

Growing community of inventors

Oxford, United Kingdom

Vincenzo Cerundolo