Zambon Group S.p.a.

Wyeth

Zach System S.p.a.

American Home Products Corporation

Bracco International Bv

Vincenzo Cannata

Giuseppe Barreca

Pietro Allegrini

Livius Cotarca

Massimo Verzini

Giorgio Soriato

Roberto Brescello

Francesco Corcella

Marco Villa

Andrea Nicoli

Fabio Bassan

Paolo Andreella

Marco Demo

Francesco Tasinato

Graziano Castaldi

Maurizio Paiocchi

Silvio Iera

Aldo Belli

Kadum A Ali

Ivan Michieletto

Michel Bernatchez

Katiuscia Arrighi

Valeriano Merli

Gaetano Marchioro

Pierre Giguere

Stefano Poli

Alessandro Rosi

Carl E Longfellow

Shridhar G Gangolli

Claudio Dal Santo

Malama K Chibwe

Corrado Velgi

The present invention relates to methods of preparing polymorphic Form A of bazedoxifene acetate and polymorphic Form A prepared by such methods.

Methods of preparing polymorphic form A of bazedoxifene acetate

The present invention relates to a process for the preparation of gabapentin and, more in particular, to a method of synthesis of 1,1-cyclohexane acetic acid monoamide, an intermediate used in the preparation of gabapentin, comprising the basic hydrolysis reaction of &#x3b1;,-diaminocarbonyl-&#x3b2;,&#x3b2;-pentamethylene glutarimide.

Process for the preparation of gabapentin

The present invention is directed to a crystalline polymorph of bazedoxifene acetate, compositions containing the same, preparations thereof, and uses thereof.

Crystalline polymorph of bazedoxifene acetate

A process and new oxazolinic intermediates for the preparation of 4-(8-chloro-5,6-dihydro-11H-benzo-[5,6]-cyclohepta-[1,2-b]-pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester (loratadine) is described. The process starts from 2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-3-methyl-pyridine, a new intermediate to obtain loratadine. 2-(4,4-dimethyl-4, 5-dihydrooxazol-2-yl)-3-methyl-pyridine is condensed with 3-chloro-benzyl-chloride and the resultant product is treated with Grignard reagent of 4-chloro-N-methyl-piperidine. [3-(2-(3-chloro-phenyl)-ethyl]-pyridin-2-yl]-1-(methyl-piperidin-4-yl)-methanone is obtained for subsequent hydrolysis. Starting from this last compound it is possible to obtain loratadine with known methods.

Process for the preparation of 4-(8-chloro-5 6-dihydro-11h-benzo-(5 6)-cyclohepta-(1 2b)-pyridin-11-ylidene-1-piperidiniecarboxylic acid ethyl ester (loratadine)

A process for the purification of gabapentin by treatment of a crude aqueous gabapentin hydrochloride solution with a strong cationic ion exchange resin.

An isomerization process of trans-5-fluoro-2-methyl-1-&lsqb;p-(methylthio)benzyliden&rsqb;inden-3-acetic acid for the treatment of sodium salt in methanol and in the presence of a base at 70&plusmn;2&deg; C. is described.

Process for the preparation of cis 5-fluoro-2-methyl-1&lsqb;p-(methylthio)benzyliden&rsqb;-inden-3-acetic acid

A method for the removal of heavy metals from solutions of organic compounds by treatment with cysteine or with an N-acylcysteine is described. Organic compounds with a content of heavy metal, for example palladium, particularly low and suitable for the preparation of compounds with pharmacologic activity can be isolated from the resultant solutions.

Process for the removal of heavy metals

Process for preparing 5-amino-2,4,6-triiodoisophthalic acid dichloride

A process is described for preparing a compound of the formula I: ##STR1## or a salt thereof; wherein X is a protecting group and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently hydrogen, C.sub.1-6 alkyl or C.sub.1-6 perfluoroalkyl, R.sub.5 is hydrogen or when n is 1 R.sub.5 taken together with R.sub.3 comprises a double bond; m is 1, 2 or 3; n is 0 or 1, and p is 0, 1 or 2.

Process for preparation of biphenyl derivatives

A process for the preparation and purification of L-5-(2-hydroxypropionylamino)-2,4,6-triiodoisophthalic acid bis-(1,3-dihydroxypropylamide) by using ion-exchange resins is described.

Process for the preparation and purification of iodinated contrast agents

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Vincenzo Cannata