Hoechst Aktiengesellschaft

Vincenz Zimmermann

Emmerich Paszthory

Hans J Nestler

Ernst Hille

Karl-Gerhard Seifert

Karl G Seifert

Diazotization of 4-phenoxy-anilines in aqueous sulfuric acid of 60 to 75% strength and decomposition of the resulting diazonium compound in sulfuric acid of the same concentration range yields the corresponding phenols in high yields and quality. These phenols are intermediate for the corresponding 4-phenoxy-phenoxy alkane carboxylic acids which are pharmaceuticals capable of reducing the blood serum lipid level.

Process for the preparation of 4-phenoxy-phenols

N-acetoacetyl-2,5-dimethoxy-4-chloroanilide is obtained in high yield and purity by suspending 2,5-dimethoxy-4-chloroaniline in water and adding the complete amount of diketene necessary altogether at the beginning of the reaction. The product is obtained in a purity allowing its use as an azoic coupling component without purification.

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Nauheim, Germany

Vincenz Zimmermann