Centre National De La Recherche Scientifique

Institut Curie

Harvard College

Immupharma France Sa

Cemag Care

Biomerieux, Inc.

Sorbonne Université

Université Pierre Et Marie Curie (paris 6)

Institute Curie

Neomps

Ecole Nationale Superieure De Chimie De Paris (enscp)

Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De Paris

Université Pierre Et Marie Curie

Ecole Nationale Superieure De Chimie De Paris

Immupharma Sa

Vincent Semetey

Jean-Paul Briand

Gilles Guichard

Romain Rodriguez, Legal Representative

Elisa Rodriguez, Legal Representative

Pierre Rodriguez, Legal Representative

Marie-Christine Galas-Rodriguez, Legal Representative

George M Whitesides

José Dugay

Gilles Francois Roger Guichard

Patrick Neuberg

Aurélie Thuleau

Arnaud-Pierre Schaffner

Jean-François Le Meur

Isabelle Fromantin

Serge Plaue

Marc (decede) Rodriguez

Vincent Linder

Samuel K Sia

Samuel W Thomas

Babak Amir-Parviz

Declan Ryan

Francis Rondelez

Lara A Estroff

Anne-Sophie Castanet

Othman Bouloussa

David Limal

Nasreddine Kebir

Zihni Basar Bilgicer

Vijay M Krishnamurthy

Aurelie Thuleau

Jose Dugay

Jean-Francois Le Meur

Marc (deceased) Rodriguez

Gilles Francois Guichard

Jean-François Lemeur

Samuel William Thomas Iii

The invention relates to a device for adsorbing odours comprising an absorbent layer and an adsorbent layer, said adsorbent layer being provided with a material permeable to volatile organic compounds (VOCs) and an adsorbent particulate filler comprising at least one spice. Such a device is particularly useful for adsorbing and masking body odours.

Device for adsorbing odours

The present invention relates to method for treating a substrate or a surface thereof bearing Si&#x2014;H groups to confer to it a physical and/or biochemical surface-modified property, wherein it comprises at least a step consisting of exposing, within a liquid medium, said substrate or a surface thereof with at least a polymer, said polymer containing: at least three reactive sites able to attach to said substrate or said surface by reacting with Si&#x2014;H groups and further creating covalent bonds, and at least a molecule or a part thereof able to confer said modified property to said substrate or said surface thereof, said step being carried out in efficient conditions to promote the covalent grafting of said polymer to said substrate or surface thereof and the molecular weight of said polymer being greater than 1000 g/mol.

Method for treating surfaces containing Si&#x2014;H groups

A method of conferring modified properties, e.g. modified physical and/or biochemical properties, to a metallic substrate surface, including at least two steps being (i) a first step including at least exposing the substrate surface to a hetero-bifunctional anchoring molecule carrying at least a silane group and at least a Agroup, the Agroup being optionally introduced within the anchoring molecule via a preliminary functionalizing step, and (ii) a second step of exposing the substrate surface to a polymer carrying at least three groups Acapable of reacting with Ain a thiol-ene reaction, the number average molecular weight of the polymer being greater than 1 000 g/mol.

Method for grafting polymers on metallic substrates

The present invention relates to a method for treating at least a surface of a substrate containing labile hydrogen atoms to confer to it cytotoxic properties or cell-adhesion properties, characterized in that it comprises at least a step consisting of exposing, within a liquid medium, said substrate or a surface thereof with at least a copolymer, said copolymer containing at least a monomer unit of type A including at least a reactive site able to attach to said substrate or said surface by covalent bonds and at least a monomer unit of type B including at least one molecule able to confer antimicrobial, antiviricidal and/or antifungicidal or cell-adhesion properties to said substrate or said surface, said step being carried out in efficient conditions to promote the covalent grafting of said copolymer to said substrate or a surface thereof.

Method for treating surfaces with copolymers

The present invention discloses a method of purifying bivalent antibodies or antibody fragments that are active at both Fab sites from a source of antibodies or antibody fragments using a non-chromatographic method that includes inducing the formation of cyclic immunoglobulin aggregates by addition of multivalent hapten to a salt solution of soluble antibodies or antibody fragments, wherein the multivalent hapten possesses a linker between the two haptens effective to prevent the binding of both haptens of the ligand to the same antibody or antibody fragment.

Purification of a bivalently active antibody using a non-chromatographic method

A method for treating a cytotoxic disease by administrating compounds having a general formula X-(A)n-Y, wherein: n varies between 6 and 20; X denotes a hydrogen atom, an RaCO, RaOCO, RaNHCO or RaSO2 group, Ra being an alkyl, alkenyl, alkynyl, aryl, aralkyl, heteroaryl group, the groups being substituted or not, on condition that X is different from H when n is equal to 6; A denotes either a group having formula (I) or (II), wherein Ri is a hydrogen atom, an amino acid side chain, an alkyl, alkenyl, alkynyl, aryl, aralkyl or heteroaryl group, said groups being substituted or not, i being an integer of between 1 and n; Y is an NRbRc, Rb and Rc group having the same meaning as given earlier for Ra.

Urea oligomers, their preparation process and pharmaceutical compositions containing them

A series of methods, compositions, and articles for patterning a surface with multiple, aligned layers of molecules, by exposing the molecules to electromagnetic radiation is provided. In certain embodiments, a single photomask acts as an area-selective filter for light at multiple wavelengths. A single set of exposures of multiple wavelengths through this photomask may make it possible to fabricate a pattern comprising discontinuous multiple regions, where the regions differ from each other in at least one chemical and/or physical property, without acts of alignment between the exposures. In certain embodiments, the surface includes molecules attached thereto that can be photocleaved upon exposure to a certain wavelength of radiation, thereby altering the chemical composition on at least a portion of the surface.

Patterning and alteration of molecules

Compounds having a general formula X-(A)n-Y, wherein: n varies between 6 and 20; X denotes a hydrogen atom, an RaCO, RaOCO, RaNHCO or RaSO2 group, Ra being an alkyl, alkenyl, alkynyl, aryl, aralkyl, heteroaryl group, the groups being substituted or not, on condition that X is different from H when n is equal to 6; A denotes either a group having formula (I) or (II), wherein Ri is a hydrogen atom, an amino acid side chain, an alkyl, alkenyl, alkynyl, aryl, aralkyl or heteroaryl group, said groups being substituted or not, i being an integer of between 1 and n; Y is an NRbRc, Rb and Rc group having the same meaning as given earlier for Ra. The compounds are used for the preparation of medicaments that are intended to treat bacterial, fungal or cytotoxic diseases and, in particular, fungal infections, such as aspergillosis and candidiasis, and resistant bacterial infections.

Urea oligomers, the preparation method thereof and pharmaceutical composition containing same

The invention concerns a pseudopeptide of at least 6 amino acids comprising at least a unit selected among the general formulae (I) and/or (II) wherein: R, Rand Reach independently of one another represent a side-chain of amino acids and can be identical or different; X represents an oxygen or sulphur atom. The invention also concerns its synthesis process, a reagent containing it, a detection kit comprising such a reagent, a method for detecting an antigen or an antibody using said pseudopeptide, and antibody or and anti-idiotype and finally a therapeutic composition.

Pseudopeptide, synthesis method, reagent and applications

A method for preparing cyclic urea compounds from at least an activated carbamic acid derivative containing an unprotected primary or secondary amine function, includes a cyclization step which consists in a reaction between the primary or secondary amine function and the carbamic acid function of the carbamic acid derivative(s).

Cyclic urea compounds and preparation thereof

Stabilized activated derivatives of carbamic acid, their process of preparation and their use for the preparation of ureas

Process for the preparation of stable activated derivatives of carbamic acid, comprising at least one protected amino group and an activated carbamic acid function, from an amino acid derivative in which the amino group is protected. The process includes: a) a step of transformation of the &#x2014;COOH group of the amino acid derivative into a &#x2014;CONgroup to obtain an acyl azide; b) a step of transformation of the &#x2014;CONgroup of the acyl azide into a &#x2014;NCO group to obtain an isocyanate; c) a step of treating the isocyanate to obtain a stable derivative of carbamic acid.

Growing community of inventors

Le Mans, France

Vincent Semetey