The General Hospital Corporation

Vincent Pai

Mehmet Toner

Ravi Kapur

Kyle C Smith

Thomas Alan Barber

Fabio Fachin

Philipp S Spuhler

Nezihi Murat Karabacak

Murat N Karabacak

Microfluidic devices are described that include a microfluidic channel, a first array of one or more magnets above the microfluidic channel, each magnet in the first array having a magnetic pole orientation opposite to a magnetic pole orientation of an adjacent magnet in the first array, and a second array of one or more magnets beneath the microfluidic channel, each magnet in the second array having a magnetic pole orientation opposite to a magnetic pole orientation of an adjacent magnet in the second array. The first array is aligned with respect to the second array such that magnetic fields emitted by the first array and second array generate a magnetic flux gradient profile extending through the channel. An absolute value of the profile includes a first maximum and a second maximum that bound a local minimum. The local minimum is located within the microfluidic channel or less than 5 mm away from a wall of the microfluidic channel. Methods of using the new devices are also described.

Microfluidic sorting using high gradient magnetic fields

Microfluidic sorting with high gradient magnetic fields using opposing arrays of adjacent magnets

Growing community of inventors

Somerville, MA, United States of America

Vincent Pai