Novartis Vaccines & Diagnostics, Gmbh

Vincent P Le

Mark Knapp

Eric J Martin

Paul A Renhowe

Hong Yang

Weibo Wang

Savithri Ramurthy

Sabina Pecchi

Sharadha Subramanian

Paul Andrew Barsanti

David Duhl

Kenneth Walter Bair

Tinya Abrams

Rama Jain

Annette Olga Walter

Ryan N Constantine

Elisa Jazan

Kris Mendenhall

Nathan Brammeier

Elizabeth J Mieuli

Anu Sharma

Megan C Phillips

Kelly Wayman

Kay Huh

Liana Marie Lagniton

Rustum Boyce

Yia Xia

Rustum S Boyce

Dirksen Bussiere

Xia Yia

Liana Marie Lagnition

The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula: 

Substituted imidazole derivates

Substituted imidazole derivatives

This invention provides methods of identifying an Eg5 binding ligand. The ligand is identified by using the atomic coordinates of an Eg5 crystal to generate a three dimensional structure. The three dimensional structure is used in molecular modeling techniques and docking experiments to identify ligands that bind to the binding pocket of Eg5. A novel binding pocket is identified. The invention also provides a crystallized Eg5 and ligand complex.

Eg5 co-crystals

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San Francisco, CA, United States of America

Vincent P Le