University of Massachusetts

Firmenich Sa

Vincent Martin Rotello

Bradley P Duncan

Ryan Francis Landis

Akash Gupta

Maria Monica Santore

Uwe Bunz

Oscar Miranda

Chang-Cheng You

Xiaoning Li

Lahoussine Ouali

Valery Normand

Ronnie Lee Phillips

Daniel Benczedi

Mark Tuominen

Huda Jerri

Krishnendu Saha

Ying Jiang

Jun Zhang

Rui Tang

Jung Zhang

Rubul Mout

Ik-Bum Kim

Yiwei Lee

Yuval Ofir

Qijun Xiao

Li-Sheng Wang

Bappaditya Samanta

Eunhee Jeoung

Sanjana Gopalakrishnan

Chandramouleeswaran Subramani

Huda A Jerri

A polymer nanoparticle includes a polymer having repeating units of formula (I) wherein X, L, and Rare as defined herein. Methods of preparing the polymer nanoparticles and compositions comprising the nanoparticles are also disclosed. The polymers nanoparticles described herein are particularly useful for the treatment of bacterial biofilms.

Polymer nanoparticle, polymer composition, method of making a polymer nanoparticle, method for treatment of bacterial biofilms, and method for detection of bacterial biofilms

Methods of preparing protein films in the presence of organofluorine compounds are provided that can produce protein films that retain the solution phase characteristics of the proteins. The protein films can be coatings for medical devices.

Generation of stable protein films using fluorous solvent

Various embodiments disclosed relate to a nanoparticle-protein complex for intracellular protein delivery. In various embodiments, the present invention provides a nanoparticle-protein complex including a nanoparticle including an amine-containing ligand. The nanoparticle-protein complex also includes a protein comprising a carboxylic acid-containing tag.

Nanoparticle-protein complex for intracellular protein delivery

The invention provides nanoparticle-stabilized nanocapsules, and methods of their preparation and use in delivery of therapeutics, such as nucleic acids. Various embodiments disclosed relate to a nanoparticle-stabilized nanocapsule. Various embodiments disclosed relate to nanoparticle-stabilized nanocapsules for nucleic acid delivery into cells. Various embodiments provide methods of using the nanocapsule for in vivo delivery of the nucleic acid materials.

Nanoparticle-stabilized nanocapsules and methods of preparation and use for nucleic acid delivery

A nanocapsule includes a liquid hydrophobic care including an essential oil, and a shell encapsulating the core. The shell includes a copolymer having repeating units of Formula (I) and (II) wherein X, L, R, R, y, and p are as described herein. A dispersion is also disclosed, wherein the dispersion includes a plurality of nanocapsules. The nanocapsules described herein are particularly useful for the treatment of bacterial biofilms. 

Stabilized polymeric nanocapsules, dispersions comprising the nanocapsules, and methods for the treatment of bacterial biofilms

A stabilized microcapsule includes a liquid hydrophobic core including an essential oil and an aromatic monoaldehyde, and a shell encapsulating the core, the shell including a plurality of amino-functionalized inorganic nanoparticles. Also disclosed is a dispersion including a plurality of the stabilized microcapsules. The microcapsules and dispersions can be particularly useful for treating a bacterial biofilm.

Nanoparticle-stabilized microcapsules, dispersions comprising nanoparticle-stabilized microcapsules, and method for the treatment of bacterial biofilms

Various embodiments disclosed relate to protein films and methods of making the same. In various embodiments, the present invention provides a method of making a protein film including placing on a substrate a protein solution, to form a precursor protein film. The protein solution includes one or more proteins. The method includes compressing the precursor protein film to form a protein film.

Protein films and methods of forming the same

The present invention relates to microcapsules with a core-shell or matrix morphology stabilized by cross-linked nanoparticles. A process for the preparation of said microcapsules comprising selecting internal crosslinking of a Pickering emulsion is also an object of the invention. Perfumed consumer products, in particular fine fragrance, home and personal care products are also part of the invention.

Maleic anhydride polymer-stabilized microcapsules

The present invention includes an article of manufacture or device, or related system, comprising a heterogeneous surface for selective analyte sensing or separation. Such an article can comprise a surface member and a plurality of spaced components extending therefrom and coupled thereto, such a surface member and spaced components providing a surface heterogeneity selected from different electrostatic interactions, different non-electrostatic interactions and a combination of such interactions, such that the interactions are at least partially sufficient for selective analyte interaction and/or separation. Each such component extension can be of a nanometer dimension about the Debye length of a medium comprising an analyte particle exposed to such a surface. An analyte particle, optionally of a mixture of particles, can be dimensioned from about 30 nm to 20 &#x3bc;m. In some embodiments, the extended components have a density at least partially sufficient for interaction of a single such component or multiple components with a single analyte particle, at a given Debye length. In other embodiments, such components have an average spatial density at least partially sufficient for selective particle interaction and/or separation.

Nanoparticle-textured surfaces and related methods for selective adhesion, sensing and separation

Textured heterogeneous surfaces and related articles as can be used in conjunction with methods for selective sensing and/or separation. When used for selective particle separation such a system can comprise a heterogeneous surface comprising a surface member and a plurality of components extending therefrom, such components spaced about and having a surface density, with heterogeneity comprising different interactions of the surface member and of the extended components with a particle exposed thereto. Various surface heterogeneities and different interactions can be utilized. However, in certain embodiments, competing electrostatic interactions, or a combination of electrostatic and non-electrostatic interactions, with a particle can be utilized. Such a system can utilize a surface member having a charge difference with respect to the components extending therefrom.

Compositions, methods and related apparatus, as can be used for selective protein detection and identification.

Methods and compositions for protein detection using nanoparticle-fluorescent polymer complexes

Compositions, methods and related apparatus, as can be used for selective pathogen detection and identification.

Methods and compositions for pathogen detection using nanoparticle-fluorescent polymer complexes

Disclosed herein is a method for generating a three-dimensional structure on a surface. The method comprises forming a layer comprising a plurality of nanoparticles on a surface; and exposing a portion of the layer to incident radiation having a defined pattern at a dosage effective to aggregate the nanoparticles in the exposed portion of the layer into a three-dimensional structure, wherein the three-dimensional structure has a shape defined by the pattern of the radiation and a height defined by the dosage of the incident radiation and a thickness of the nanoparticle layer. Alternatively, the method comprises forming a layer comprising a plurality of nanoparticles on a surface of a three-dimensional template; and exposing at least a portion of the layer to incident radiation at a dosage effective to aggregate the nanoparticles in the exposed portion of the layer into a three-dimensional structure that corresponds to the three-dimensional template.

Growing community of inventors

Amherst, MA, United States of America

Vincent Martin Rotello