Universitéde Strasbourg

Institut National De La Sante Et De La Recherche Medicale

Vaxine Pty Ltd

Thales

Inserm (Institut National De La Sante Et De La Recherche Medicale)

Inserm

Vincent Marion

Nikolai Petrovsky

Hélène Dollfus

Anaïs Mockel

The present invention relates to peptides for the treatment of diabetes and associated disorders.

Peptides for treatment and prevention of diabetes and associated disorders

The present invention relates to the identification of ALMS1 as the missing player involved in the regulation of the insulin-mediated glucose uptake through GLUT4 sorting vesicles, and to the down-regulation of ALMS1 by &#x3b1;PKC. Accordingly, the present invention relates to a molecule capable of preventing the binding of &#x3b1;PKC on ALMS1 for use for treating or preventing diabetes, in particular type 2 diabetes. In addition, the present invention relates to a method for identifying molecule capable of preventing the binding of &#x3b1;PKC on ALMS1.

Target for diabetes treatment and prevention

The present invention relates to peptides for the treatment or prevention of nonalcoholic fatty liver disease (NAFLD), non-alcoholic fatty liver (NAFL), non-alcoholic steatohepatitis (NASH), hepatic steatosis (fatty liver), liver inflammation, cirrhosis, hepatocellular carcinoma or fibrosis, especially liver fibrosis.

Peptides for treatment and prevention of nonalcoholic fatty liver disease and fibrosis

The present invention relates to peptides for the treatment or prevention of diabetes mellitus and associated disorders.

Peptides for treatment and prevention of hyperglycaemia

The present invention relates to a pharmaceutical composition comprising an inhibitor of eIF2&#x3b1;, a compound increasing the expression and/or activity of protein BiP and/or an inhibitor of Caspase-12, preferably an inhibitor of eIF2&#x3b1; and a compound increasing the expression and/or activity of protein BiP. The present invention also relates to pharmaceutical compositions and methods for treating retinal degeneration related to ciliary dysfunction.

Compositions and methods for the treatment of retinal degeneration

A method of color image processing comprises at least the following steps: the color image is converted into an intermediate image comprising components that depend solely on the H and S components of the original image in an HSV or HLS representation; the intermediate image comprising at least two components X and Y, determined by functions especially of the H component, these functions taking the same value when the H component is zero or equal to one; a new image comprising only one component is generated from the intermediate image, the component of this new image being a function of the components of the intermediate image. The disclosed method can be applied especially to the heightening of contrast in remote surveillance, and to image processing before segmentation in mobile robotics.

Growing community of inventors

Schiltigheim, France

Vincent Marion