Sanofi

Arkema France

Aventis Pharma S.a.

Sanofi-aventis

Vincent Leroy

Jean-Christophe Carry

Olivier Duclos

Sergio Mallart

Maria Mendez-Perez

Stephanie Deprets

Fabienne Chatreaux

Fabrice Vergne

Dominique Melon-Manguer

Baptiste Ronan

Eric Bacque

Michael Yves Bernard

Dmitri Colesnic

Carine Fouilliart

Michel Tabart

Fabrice Viviani

Marcel Patek

Martin Smrcina

Anil Nair

Catherine Souaille

Anke Steinmetz

Jean-Philippe Letallec

Kirsten Bjergarde

Emmanuel Conseiller

Mark Dodson

Stéphanie Deprets

Martha Ackerman-Berrier

Laurent Lepinay

Virginie Ducastel

Thierry Soula

Germain Fauquet

Laurent J C Lepinay

Michael Y Bernard

The present invention relates to a rheology additive, according to which A) said additive consists of: a) at least one symmetrical fatty diamide of formula (I): (AGH)-CONH-(PMDA)-NHCO-(AGH) (I) with: (AGH): hydroxylated fatty acid residue R1CO2H, without —CO2H group, with R1 of C18 to C20 comprising a hydroxyl group, —NHCO— or —CONH—: amide group, —(PMDA): residue without amine groups of 1,5-pentamethylenediamine; or alternatively according to which: B) said additive comprises: a) at least one symmetrical fatty diamide as defined above according to formula (I) and, in addition, b) at least one other symmetrical fatty diamide of formula (II): (AGH)-CONH-(R)-NHCO-(AGH) (II) with (AGH), —NHCO— and —CONH— having the same definition as that above in said formula (I), and (R) being the residue without amine groups of a diamine, other than (PMDA), chosen from a cycloaliphatic, aliphatic or aromatic diamine.

Rheological additive based on optionally biosourced 1,5-pentamethylenediamine

The invention relates to a fatty amide which is a di- or triamide based on a polyether diamine or triamine which can be used as organogelator and in particular as rheology additive, said amide comprising a specific mixture of hydroxylated fatty acids and short hydroxylated acids. The invention also relates to a formulation composition using said fatty amide as rheology additive and to its use with this aim in coating, adhesive or PVC plastisol compositions and in particular transparent or non-transparent mastic compositions. Said rheology additive has the advantage of not needing a specific activation process before use, in contrast to the other known fatty amide additives based on hydrogenated castor oil derivatives.

Rheology additives based on hydroxylated di-or tri-amides and mixtures therof

The invention relates to a fatty acid diamide-based rheology additive composition, which is pre-activated and pre-concentrated in fatty acid diamide, comprising: a) from 5% to 30% by weight of at least one fatty acid diamide based on 12 hydroxystearic acid and on a linear, in particular C5, C6 or C7, aliphatic diamine, b) from 70% to 95% by weight of at least one monofunctional (meth)acrylic reactive diluent comprising a cycloaliphatic group or several cycloaliphatic groups, the % being expressed relative to a)+b). It also relates to a process for preparing the composition and to the use thereof as a rheology additive in reactive binder compositions such as coating, moulding, composite material, anchor bolt or sealant compositions or photocrosslinkable compositions for stereolithography or for 3D printing of objects by inkjet.

Fatty diamide additive composition preconcentrated and pre-activated in a reactive diluent

The present invention relates to compounds of formula (1): wherein R6 is &#x2014;CONHor a &#x2014;C(R)(R)(OH) group; R is a substituted phenyl or heteroaryl group; R7 is an optionally substituted aryl or heteroaryl group. Process for the preparation thereof and therapeutic use thereof.

Thienopyrimidine derivatives, processes for the preparation thereof and therapeutic uses thereof

The present invention relates to compounds of formula (I): wherein R6 is &#x2014;CONHor a &#x2014;C(R)(R)(OH) group; R is a substituted phenyl or heteroaryl group; R7 is an optionally substituted aryl or heteroaryl group. Process for the preparation thereof and therapeutic use thereof.

The present invention relates to a composition based on fatty acid diamide comprising: a) from 92% to 100% by weight of one or more fatty acid diamides, treated in situ by a neutralizing agent so as to reduce the residual amine content to a residual amine number, expressed in mg KOH/g, which remains less than 0.5, b) optionally, up to 8% by weight of at least one amorphous or semicrystalline oligomer with a Tg of greater than 60&#xb0; C., with the sum of the % by weight a)+b) being equal to 100% by weight of the said diamide composition and with a) and b) being miscible as a blend.

Additives made from fatty diamides for nucleophile-sensitive cross-linkable compositions

The present invention relates to therapeutic uses of the compounds of formula (I): wherein R6 is &#x2014;CONHor a &#x2014;C(R)(R)(OH) group; R is a substituted phenyl or heteroaryl group; R7 is an optionally substituted aryl or heteroaryl group.

Therapeutic uses of novel thienopyrimidine derivatives

The present invention relates to imidazolone derivatives of formula (I) to methods of preparing such derivatives, intermediates thereto, pharmaceutical compositions comprising such derivatives, and methods of inhibiting protein kinase, and methods of treatment comprising administration of such derivatives.

Imidazolone derivatives, preparation thereof as drugs, pharmaceutical compositions, and use thereof as protein kinase inhibitors, in particular CDC7

The disclosure relates to compounds of formula (I): which modulate the activity of proteins, particularly kinases, and to compositions containing the same, and to the use thereof as medicaments, in particular as anticancer agents.

7-substituted aza-indazoles, compositions containing same, production method and use thereof

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Paris, France

Vincent Leroy