Purdue Research Foundation

University of Minnesota

Boston University

Vincent Jo Davisson

Meiguo Xin

Jonathon Michael Gast

Matthew David Bartolowits

Shirshendu K Deb

Aaron Raymond Lindstrom

Giselle Marcelline Knudsen-Mooney

Laurie Louise Parker

Dor Ben-Amotz

Dongmao Zhang

Yong Xie

Melissa Mrozek

Corasi Ortiz

Tzu-Yi Yang

Naoaki Fujii

Robert A Davey

Ebola virus and Marburg virus are filoviruses and are responsible for outbreaks that cause up to 90% fatality, including the recent outbreak in West Africa that has resulted in over 11,000 deaths. The present disclosure generally relates to series novel arylnaphthalene compounds, having a formula (I) or a pharmaceutically acceptable salt thereof, as a vacuolar-ATPase inhibitor that are useful for the treatment for a broad spectrum of viral infections, including those infections caused by filoviruses. Pharmaceutical composition matters and methods of use are within the scope of this invention.

Arylnaphthalene compounds as vacuolar-ATPase inhibitors and the use thereof

Ebola virus and Marburg virus are filoviruses and are responsible for outbreaks that cause up to 90% fatality, including the recent outbreak in West Africa that has resulted in over 11,000 deaths. The present disclosure generally relates to novel arylnaphthalene compounds as a vacuolar-ATPase inhibitor that are useful for the treatment of various viral infections, including those infections caused by filoviruses. Pharmaceutical composition matters and methods of use are within the scope of this invention.

The present invention relates to series of compounds as an inhibitor targeting Proliferating Cell Nuclear Antigen (PCNA). Pharmaceutical compositions of those compounds and methods of using them in the treatment of cancer are within the scope of this disclosure.

Inhibitors for proliferating cell nuclear antigen and uses

The invention provides cellular assays for detecting the activity of one or more kinase from multiple conditions simultaneously, by encoding biochemically identical substrates with isotope labels that enable them to be distinguished in pooled samples by mass spectrometry.

Kinase activity detection methods

Organic dyes that are covalently bonded multimers or higher order symmetrical structures where one or more dye units may optionally contain deuterium substitutions are disclosed. The disclosed dyes are particularly useful for optical coatings, new optical nanomaterials, high density storage devices. The structural and optical characteristics of the disclosed dyes provide avenues for increased information-content through surface-enhanced Raman resonance spectroscopy.

Higher order structured dyes with enhanced optical features

The present disclosure provides isotopically substituted compounds of the formula (II): wherein T, U, V, W, X, Y, Z, R, R, R, Rand Rare as defined in the detailed description. The method for detection and quantification using the same is also disclosed.

Reagents for biomolecular labeling, detection and quantification employing raman spectroscopy

The present disclosure provides isotopically substituted compounds of the formula (I): wherein T, U, V, W, X, Y, Z, R, R, R, Rand Rare as defined in the detailed description. The method for detection and quantification using the same is also disclosed.

Reagents for biomolecular labeling, detection and quantification employing Raman spectroscopy

Micro-droplets of liquid confining organic molecules of interest are dried on selected planar solvo-phobic substrates under conditions facilitating segregated precipitation of the larger, less soluable analytes toward edge portions of the deposit. Micro-spectrometer imaging using white light and FTIR false color can identify points of interest, and the same optics generally directed perpendicularly to the substrates selectively captures normal Raman spectra from selected points in the deposit. The spectra are manipulated using various data techniques to extract reliable information concerning analytes present at pico-Molar levels. The selected spots can also be subjected to FTIR spectroscopy followed by MALDI mass spectroscopy to obtain a variety of information from the identical specimen.

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West Lafayette, IN, United States of America

Vincent Jo Davisson