Biomarin Pharmaceutical Inc.

Poxel Sa

Deuterx, LLC

Microdose Therapeutx, Inc.

Collagen Medical, LLC

Nanotherapeutics, Inc.

Salarius Pharmaceuticals, Inc.

Catalyst Medical

Vincent Jacques

James R Rusche

Norton P Peet

Jasbir Singh

Sheila DeWitt

Zhaoda Zhang

Leonardus Van Der Ploeg

Peter Caravan

Aaron Sato

Sharon Shacham

Dilara McCauley

Leonardus H T Van Der Ploeg

Oren Becker

Ashis K Saha

Yael Marantz

Andrew Kolodziej

Richard J Looby

Stephane A Dumas

Sébastien Bolze

Aida Abujoub

Pini Orbach

Steffi K Koerner

Wei-Chuan Sun

Efrat Ben-Zeev

A Sekar Reddy

Biplab Kumar Das

David R Buckler

Laure Françoise Valérie Navarre

Michael Xie

Shomir Ghosh

Boaz Inbal

Mercedes Lobera

John C Amedio, Jr

Kevin Zhou

Stuart Levy

Shirley Kalogeropoulos

Matthew Greenfield

William Perrault

Emeline Gardette

Gali Golan

Sheila Dewitt

Leonardus HT Van Der Ploeg

Dilara Mccaulay

The present disclosure provides a crystalline form of enantiopure deuterium-enriched bupropion, pharmaceutical compositions, and methods of treating mood disorders, neurological disorders, movement disorders, cardiovascular disorders, metabolic disorders, and other disorders using a crystalline form of enantiopure deuterium-enriched bupropion.

Solid forms of enantiopure deuterium-enriched bupropion and methods of use thereof

The invention provides 5-deuterium-enriched 2,4-thiazolidinediones (e.g., 5-[4-[2-(5-ethyl-2-pyridyl)-2-oxoethoxy]benzyl]-5-deutero-thiazolidine-2,4-dione), deuterated derivatives thereof, stereoisomers thereof, pharmaceutically acceptable salt forms thereof, and methods of treatment using the same.

5-deutero-2,4-thiazolidinedione derivatives and compositions comprising and methods of using the same

The invention provides deuterium-enriched isoindolinonyl-azepanediones, deuterium-enriched oxoquinazolin-3(4H)-yl-azepanediones, related compounds, pharmaceutical compositions, and methods of using such compounds and pharmaceutical compositions to treat cancer, angiogenesis disorders, immune disorders, and other medical disorders.

Deuterium-enriched isoindolinonyl-azepanediones and related compounds and methods of treating medical disorders using same

The invention provides methods of synthesis of enantiopure deuterium enriched R-pioglitazone with structure of compound (IV), or a pharmaceutically acceptable salt thereof: The invention further provides chemical intermediates useful in the synthesis of compound (IV), and methods of synthesizing those intermediates.

Methods of synthesizing enantiopure deuterium-enriched pioglitazone

Provided herein are crystalline forms of deuterium-enriched (R)-pioglitazone and compositions thereof. Also provided herein are methods of using the crystalline forms of deuterium-enriched (R)-pioglitazone and compositions thereof.

Crystalline forms of deuterium-enriched pioglitazone

The invention provides enantiopure deuterium-enriched pioglitazone, pharmaceutical compositions, and methods of treating neurological disorders, cancer, respiratory disorders, metabolic disorders, and other disorders using enantiopure deuterium-enriched pioglitazone. A preferred aspect of the invention provides methods of treating Alzheimer's disease, non-small cell lung cancer, hepatocellular carcinoma, and chronic obstructive pulmonary disease using enantiopure deuterium-enriched pioglitazone.

Methods of treating neurological, metabolic, and other disorders using enantiopure deuterium-enriched pioglitazone

This invention relates to generally inhibiting histone deacetylase ('HDAC') enzymes (e.g., HDAC1, HDAC2, and HDAC3).

Histone deacetylase inhibitors

Disclosed herein are compounds of formula (I), and methods of inhibiting histone deacetylase ('HDAC') enzymes (e.g., HDAC1, HDAC2, and HDAC3) using compounds of formula (I). 

HDAC inhibitors

The invention provides deuterium-enriched isoindolinonyl-piperidinonyl conjugates, deuterium-enriched oxoquinazolin-3(4H)-yl-piperidinonyl conjugates, pharmaceutical compositions, and methods of using such conjugates and pharmaceutical compositions to treat cancer, angiogenesis disorders, immune disorders, and other medical disorders.

Deuterium-enriched isoindolinonyl-piperidinonyl conjugates and oxoquinazolin-3(4H)-yl-piperidinonyl conjugates and methods of treating medical disorders using same

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Somerville, MA, United States of America

Vincent Jacques