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Centre National De La Recherche Scientifique

UniversitÉ´de Rouen

Institut National Des Sciences Appliquees De Rouen (insa)

Institut National Des Sciences Appliquees De Rouen

Vfp Therapies

Insa (institut National Des Sciences Appliquees) De Rouen

Vincent Gembus

Vincent Levacher

Francis Marsais

Philippe Jubault

Pierre Bohn

Nicolas Le Fur

Christophe Hoarau

Jean-Francois Bonfanti

David Graig McGowan

Jerome Emile Georges Guillemont

Cyril Papamicael

Ludovic Peauger

Marie-Laurence Dumartin-Lepine

Jean-François Bonfanti

David Graig Mc Gowan

This invention relates to 1,2,4-triazine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections. 

1,2,4-triazine derivatives for the treatment of viral infections

A compound of formula (I) in which the dotted lines indicate the presence of at least one double bond; n=0 to 4; Rand Rare H, or when n=1, Rand Rcan also form together a double bond between the carbon atoms, and m=0, 1 or 2, Z is CH or N or Z is C and &#x2014;CHR&#x2014; is &#x2550;CH&#x2014; linked by the double bond to cyclopentanone; or &#x2212;(&#x2212;)- is absent, and Z is NH, &#x3e;N-alkyl, &#x3e;N-phenyl, &#x3e;N-benzyl or &#x3e;N heteroaryl; Ris alkyl, aryl or heteroaryl which can be optionally substituted; EWG represents an electron withdrawing group selected from the group comprising COOR, COSR, CONRR', CN, COR, CF, SOR, SOR, SONRR&#x2032;, SONRR&#x2032;, NO, halogen, heteroaryl; and the pharmaceutical salts and stereisomers thereof. The compounds of formula (I) are potent in the treatment of neurodegenerative diseases such as Alzheimer's disease. 

Oxidisable pyridine derivatives, their preparation and use as anti-alzheimer agents

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Rouen, France

Vincent Gembus