E.i. Dupont De Nemours and Company

Vincent G Witterholt

David L Anton

Barry Stieglitz

Robert DiCosimo

Robert Donald Fallon

Fateme Sima Sariaslani

King-Mo Sun

Masuo Toji

Daniel Shaw James

Jeffrey Arthur Sternberg

Thomas A Sullivan

This invention relates to the enantioselective biologically-catalyzed hydrolysis of certain racemic nitriles to the corresponding R- or S-amides, chemically or biologically-catalyzed hydrolysis of the amides to the corresponding R- or S-acids in a batch process or in a continuous process that employs racemization and recycling of enantiomeric nitrile intermediates, the racemic nitriles being selected from the group, A--C(R.sup.1)(R.sup.2)CN, wherein A, R.sup.1 and R.sup.2 are as defined in the text, as well as certain biological materials employed to catalyze the process.

Process for the preparation of enantiometric 2-alkanoic acid amides from

This invention provides a process for enrichment of enantiomers of .alpha.-tertiary carboxylic acid esters from mixtures of corresponding esters using a biocatalyst comprising microbial cells, or partially or highly purified enzyme preparations. The enantiomeric ester products are useful as intermediates for the preparation of pharmaceutically and agriculturally active compounds.

Enzymatic process for the preparation of chiral .alpha.-tertiary

Imidazole and triazole carboxylates, and processes for preparing

A process for the production of pyruvic acid involving the enzymatic reaction of L-lactic acid and oxygen in an aqueous solution in the presence of catalysts glycolate oxidase ((S)-2-hydroxy-acid oxidase, EC 1.1.3.15) and catalase (EC 1.11.1.6). High yields of pyruvate at high purity can be achieved at commercially acceptable concentration without substantial product inhibition of the enzyme.

Process for the preparation of pyruvic acid using permeabilized

A three step process for preparing 2-hydroxybenzenesulfonamide from 2,4-dichlorophenol by treatment with chlorosulfonic acid followed by amination to form the dichlorohydroxysulfonamide and finally dehalogenation.

Process for the preparation of 2-hydroxybenzenesulfonamide

The novel copper phthalocyanine-based compound ##STR1## WHERE N IS AN AVERAGE NUMBER OF 3 TO 4, A IS 0 TO 3 BUT LESS THAN N, AND CPC is copper phthalocyanine, and its acid solutions are blue dyes particularly for paper and have excellent bleedfastness. The compound is prepared by reacting copper phthalocyanine sulfonyl chloride with the cyanoamino compounds formed from the reaction between acrylonitrile and ethylenediamine.

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Wilmington, DE, United States of America

Vincent G Witterholt