Laboratoires Goemar

Ase & Bio

Laboratories Goemar

Vincent Ferrieres

Jean-Claude Yvin

Frank Jamois

Daniel Plusquellec

Isabelle Laurent

Karine Descroix

Vaclav Vetvika

The present invention relates to the use of at least one compound of formula (I) or (II), in which Ris H and n is an integer from 2 to 10, for the preparation of a medicament for treating diseases chosen from the group comprising tumour, cancer, viral disease, bacterial disease, fungal disease, disease of the immune system, auto-immune disease or disease linked to a deficiency in immunostimulation, in human beings and warm-blooded animals. The invention also relates to new products having a mannose or mannitol termination as well as a method for preparing them. 

Use of modified oligo-&#x3b2;-(1,3)-glucans for treating diseases of the immune system, oligo-&#x3b2;-(1,3)-glucan-(1,3)-mannose, oligo-&#x3b2;-(1,3)-glucan-(1,3)-mannitol and derivatives thereof, methods for preparing them and medicaments containing them

The present invention relates to a novel method of chemically preparing functionalized derivatives of &#x3b2;-(1,3)-glucans, enabling obtaining oligosaccharides which are free or which comprise specific groups such as, for example, sulphate, phosphate, methyl, in pre-defined positions. This method includes a reaction between a glycosyl donor of formula (Ia) or (Ib) and a glycosyl acceptor of formula (II), defined in the claims. Application: Preparation of biologically active compounds which can be used in the agricultural, cosmetic or pharmaceutical fields.

Method for preparing functionalized &#x3b2;-(1,3)-glucan derivatives

The invention concerns a method for preparing Laminaribiose comprising a step for glycoside binding between a donor and an acceptor of glycosyl. The invention is characterized in that the glycosyl donor is in pyranose form and corresponds to formula (II); the glycosyl acceptor is in furanose form and corresponds to formula (III); said binding step is performed in solution in an anhydrous organic solvent, at a temperature ranging between &minus;80&deg; C. and 40&deg; C., for a time interval ranging between 1 minute and 8 hours, in the presence of a suitable promoter.

Method for laminaribiose synthesis

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Gahard, France

Vincent Ferrieres