Direct Therapeutics, Inc.

Vincent Decrescito

Richard L Kronenthal

Dean M McBeth

Dennis D Pietronigro

Disclosed are compositions and methods for the facile perfusion of a tissue with active agents following direct intra-tissue injection. Targets may consist of cells, cellular components, and/or extracellular components. The high perfusion efficiency permits high concentrations of active agents to be delivered to tissue targets resulting in high degrees of efficacy and in some instances the production of novel pharmacological activities of an active agent previously unknown or previously unattainable in vivo.

Method for tissue perfusion

In a method and apparatus for delivering a composition to a targeted area of tissue, exposure of a non-targeted tissue to the composition is minimized. The apparatus has at least one needle-like shaft which is inserted through a track in the non-targeted tissue to deliver the composition to the targeted tissue through an opening in the shaft. The track may be a naturally occurring lumen in a tissue, such as a vascular lumen, or may be a track created surgically by a diagnostic instrument, or by the needle-like shaft of the present apparatus. A valve-like mechanism closes the opening in the shaft to prevent premature delivery of the composition during insertion of the shaft, and to prevent loss of composition during withdrawal of the shaft. The valve-like mechanism also prevents excessive delivery of the composition to targeted tissue. An annular dam is mounted on an exterior portion of the shaft near the opening. When the opening in the shaft has been suitably positioned in the targeted tissue, the dam is radially expanded to prevent quantities of composition intended for delivery to the targeted tissue from flowing away from the targeted tissue along the track though which the shaft is inserted.

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Malverne Park, NY, United States of America

Vincent Decrescito