Sorin Crm Sas

Universitè Catholique De Louvain

Vincent Callegari

Stéphane Befahy

Hervé Mevel

Hervé Mével

Jean Delbeke

Sophie Demoustier-Champagne

Stéphane Béfahy

Lucas Leprince

Benoit Gerard

The present invention relates to an implantable probe comprising a sleeve adapted to be wound around an elongated cylindrical organ, such as a vagus nerve. The sleeve comprises a sheet of elastically deformable material carrying a detection/stimulation electrode being prestressed so as to allow its self-winding from an initial position where the sheet is held under stress in the deployed state to a final position where the sheet is freely spirally wound forming a sleeve around the organ. The sheet is delimited by inner and outer lateral edges of the sleeve after winding, a first transverse edge joining the first homologous ends of the first lateral edge and the second lateral edge, and a second opposite transversal edge joining homologous second ends of the first lateral edge and the second lateral edge. In the final position of the sleeve, the sheet comprises at least one area having a constraint near the first and/or second transverse edge.

Implantable probe comprising a sleeve, particularly for the stimulation of a nerve, and manufacturing method for said sleeve

The disclosure relates to implantable probes. An implantable probe includes a sleeve capable of being wound around an elongate organ of cylindrical shape, and includes a sheet of elastically deformable material that supports at least one electrode. The sheet is prestressed in such a way as to allow it to self-wind from an initial position, in which the sheet is kept stressed in the deployed state, to a final position, in which the sheet is wound freely in a spiral to form a sleeve around the organ, with the first face, which supports the electrodes, being directed towards the inside. The sheet is delimited by an outer lateral edge of the sleeve after winding, an inner lateral edge of the sleeve after winding, and a first transverse edge and a second, opposite transverse edge. The sheet includes perforations located in proximity to the first and/or second transverse edge.

Implantable probe comprising a perforated sleeve

According to a first aspect, the invention relates to a device () for electrochemically releasing a composition and comprising: one working electrode () comprising an electroactive conjugated polymer () containing or doped with said composition, a counter electrode (), and a reference electrode (). The device () is characterized in that it comprises electrical means () connected to the working electrode () and to the counter electrode () for obtaining at said working electrode () at least one composition releasing sequence () with respect to said reference electrode (), each composition releasing sequence () comprising: a first voltametric pulse (), followed by a rest period () during which no current is able to flow through said working electrode (), followed by a second voltametric pulse (), followed by an intermediate period () during which no current is able to flow through said working electrode ().

Device for electrochemically releasing a composition in a controlled manner

A cuff for use in nerve stimulation includes a sheet of elastomer having at least one electrode and being pre-stressed so as to allow its spiral self-winding to form a cuff around the nerve. The sheet is delimited by a first width defining an outer edge of the cuff after winding, a second width defining an opposite inner edge, a first length and a second opposite length. The first width is at both ends connected to the two lengths by a respective bevel edge forming an oblique angle relative to the direction of greatest dimension of the sheet.

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Corbais, Belgium

Vincent Callegari