Assistance Publique-hopitaux De Paris

Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

UniversitÉ De Paris

Universite De Versailles-st Quentin En Yvelines

Ecole Nationale Superieure De Chimie De Paris

Vincent Boudy

Marie-Caroline Husson

Sandrine Graff De Faget

Thomas Storme

Stéphane Auvin

Pascal Vaconsin

Nathalie Mignet

Johanne Seguin

Kathia Lemdani

Benoît D'Hayer

Imane Boucenna

Laurent Royon

Pierre Colinart

Robert Malafosse

Annick Tibi

Claude Capron

Stephane Auvin

Benoit D'hayer

The present invention concerns a thermosensitive polymeric hydrogel comprising at least one thermosensitive copolymer, one aqueous solution, and a mucoadhesive excipient, wherein said thermosensitive polymeric hydrogel further comprises at least one immunostimulatory adjuvant and/or at least one cytokine and/or at least one chemokine and/or atleast one heat shockprotein. Another object of the invention is a thermosensitive polymeric hydrogel according to the invention for use in the treatment of tumors or metastasis in a subject having a cancer, preferably a metastatic cancer.

Immunomodulation after locoregional anti-tumoral treatment

Provided is a fast-dissolving effervescent pharmaceutical formulation of pyridoxal-5-phosphate, and to the use thereof in the treatment of neonatal epilepsy and also of metabolic disorders with a need for pyridoxal-5-phosphate.

Effervescent formulation based on pyridoxal-5-phosphate

A gelling formulation containing ketamine or a pharmaceutically acceptable salt thereof in water, a poloxamer and one or more pharmaceutically acceptable mucoadhesive agents is provided. Also provided is a method of using the formulation for pain treatment.

Gelling formulation containing ketamine

The invention related to a gelling formulation including calcium gluconate in solution in water and a poloaxmer and to the use thereof in the treatment of hydrofluoric acid burns.

Gelling formulation based on calcium gluconate

Growing community of inventors

Paris, France

Vincent Boudy