Omeros Corporation

Rayner Intraocular Lenses Limited

Vincent A Florio

Gregory A Demopulos

Patrick W Gray

Neil S Cutshall

George A Gaitanaris

John E Bergmann

Hongkui Zeng

Rene Onrust

John Hohmann

The present invention provides methods for inhibiting postoperative inflammatory conditions following ophthalmologic surgical procedures by administering intraocularly during an ophthalmologic surgical procedure a solution including a nonsteroidal anti-inflammatory agent and an alpha-1 adrenergic mydriatic agent, such as a liquid irrigation solution of ketorolac and phenylephrine.

Anti-inflammatory and mydriatic intracameral solutions for inhibition of postoperative ocular inflammatory conditions

A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a therapeutically effective amount of a PDE7 inhibitory agent. An aspect of the invention provides for the administration of a PDE& inhibitory agent in conjunction with a dopamine agonist or precursor, such as levodopa. In another aspect of the invention, the PDE7 inhibitory agent may be selective for PDE7 relative to other molecular targets (i) known to be involved with the pathology of Parkinson's disease or (ii) at which other drug(s) that are therapeutically effective to treat Parkinson's disease act.

Use of PDE7 inhibitors for the treatment of movement disorders

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Seattle, WA, United States of America

Vincent A Florio