St. Jude Children's Research Hospital

Aviara Pharmaceuticals, Inc.

Vincent A Boyd

Brandon M Young

Nagakumar Bharatham

R Kip Guy

P Jake Slavish

William Robert Shadrick

Jeanine E Price

Anang Shelat

Ronald J Biediger

Robert V Market

Michele A Benish

Lindsay Bonner Hardy

Thomas P Thrash

In one aspect, compounds and compositions that modulate a bromodomain and methods of making and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with inhibition of a bromodomain such as, for example, cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Tetrahydroquinoline-based bromodomain inhibitors

Provided herein are compounds and pharmaceutical compositions of formula I where R, R, R, R, Rand Rare as described herein. Also provided pharmaceutically acceptable salts or stereoisomers of these compounds. In addition methods are provided for inhibiting the binding of an integrin to treat various pathophysiological conditions.

Propionic acid derivatives and methods of use thereof

In one aspect, the invention relates to novel, broad-spectrum anti-viral, pyrimidinone compounds, methods of use, compositions and kits useful in treating and/or preventing influenza. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Pyrimidinone compounds and methods for treating influenza

Growing community of inventors

Tyler, TX, United States of America

Vincent A Boyd