International Business Machines Corporation

Brown University

Vince Siu

Minhua Lu

Evan G Colgan

Russell Alan Budd

John Ulrich Knickerbocker

Gustavo Alejandro Stolovitzky

Huan Hu

Noel C Codella

Hariklia Deligianni

Bing Dang

Jonathan Hudson Connell, Ii

Nalini Kanta Ratha

Sufi Zafar

Benjamin H Wunsch

Mareva B Fevre

Joseph W Ligman

Prabhakar Nandavar Kudva

Venkat K Balagurusamy

Nixon Cheaz

Hui Wu

Bo Wen

Donna N Eng Dillenberger

Christopher Frank Codella

James Lupton Hedrick

Henri Lezec

James V Codella

Matthew Harrison Tong

Ashwin Dhinesh Kumar

Jian Zhang

Clayton M Billups

Sahil Dureja

Youssef Anthony Asaad

Kuan Yu Hsieh

Domenico Pacifici

Tayhas G R Palmore

Vihang Mehta

Alec Roelke

Steve Rhieu

Jing Feng

Myron Plugge

A liquid metering and mixing system for preparing a plurality of samples for analysis. The system includes: a liquid metering apparatus disposed in fluid communication with a sample holder and a plurality of reaction chambers and configured to meter a volume of a liquid into each of the plurality of reaction chambers, wherein each of the plurality of reaction chambers includes a reagent; and a mixing apparatus comprising a plurality of mixing elements, wherein each of the plurality of mixing elements is disposed in a corresponding reaction chamber of the plurality of reaction chambers and is adapted to mix the volume of the liquid with the reagent in preparation for analysis.

Enclosed, multi-chamber metering and mixing system used for urinalysis

Aspects of this disclosure include a recall notification method, a method for communicating an action to be performed by a device, and a method of operating a relay service by a network device. One embodiment of the recall notification method may comprise periodically transmitting, by a network interface of a medical device implanted in a user's body, a poll request to a recall service endpoint. The method may further comprise receiving, by the network interface in response to the poll request, a recall notification; and in response to receiving the recall notification, directly notifying the user.

Reverse recall notification system

An apparatus includes a substrate, an array of channels disposed in the substrate, wherein first ends of the channels are exposed to an outside the apparatus, a material disposed in the channel that promotes growth of neural tissue, a plurality of electrodes disposed at second ends of the channels, wherein each channel is aligned with a respective one of the electrodes, and a chip electrically connected to the electrodes.

Biological neuron to electronic computer interface

One or more embodiments include antimicrobial bandages with nanostructures, formation thereof, and usage thereof to facilitate wound healing. In one embodiment, a bandage apparatus that facilitates healing a wound is provided. The bandage apparatus includes a substrate having an attachment mechanism that facilitates removably attaching the substrate to a part of a body having the wound. The bandage apparatus also includes a nanostructure film provided on a surface of the substrate and configured to contact the wound when the substrate is attached to the part of the body having the wound, wherein the nanostructure film includes a plurality of nanostructures.

Antimicrobial bandage with nanostructures

A structure, apparatus, and method are disclosed. A silicon substrate with a microfluidic system that receives a sample fluid and prepares an analyte solution received by a reservoir containing a sensing surface is electrically connected to a semiconductor device. The structure includes a component for receiving a sample fluid, a component for preparing the sample fluid, a CRISPR system for cleaving a reporter species when the sample fluid contains a target sequence, a sorting component for separating the cleaved reporter species from the sample fluid and the CRISPR products, a cavity for receiving an analyte solution containing the cleaved reporter species, and a sensing surface in the cavity. The sensing surface detects electrical signals induced by reaction events in the analyte solution.

Integrated silicon platform for electronic biosensors

Techniques for quantitative colorimetric liquid analysis with color and turbidity correction are provided. In one aspect, an optical detector includes: a vessel for containing a liquid sample; a light source on a first side of the vessel; a first sensor on a second side of the vessel opposite the first side and along a light path of the light source; and a second sensor on a third side of the vessel at an angle &#x3b8; with respect to the light path. A method for quantitative measurement of an analyte is also provided, as is a method for color and turbidity analysis.

Optical sensor system for quantitative colorimetric liquid analysis

A method, a computer program product, and a computer system for classifying bacteria. The method comprises extracting a morphology signature corresponding to one or more bacteria and extracting a motility signature corresponding to the one or more bacteria. The method further comprises merging the morphology signature and the motility signature into a merged vector signature and classifying the one or more bacteria based on the merged vector signature.

Bacteria classification

Techniques for colorimetric based test strip analysis and reader system are provided. In one aspect, a method of test strip analysis includes: illuminating a test strip wetted with a sample with select spectrums of light, wherein the test strip includes test pads that are configured to change color in the presence of an analyte in the sample; obtaining at least one digital image of the test strip; and analyzing color intensity from the at least one digital image against calibration curves to determine an analyte concentration in the sample with correction for one or more interference substances in the sample that affect the color intensity. A calibration method and a reader device are also provided.

Accurate colorimetric based test strip reader system

An apparatus having a spectrometer and techniques for use thereof for efficient and effective point-of-care diagnostics are provided. In one aspect, a device is provided. The device includes: an intake port; fluidic channels connecting the intake port to a detecting chamber(s), wherein the detecting chamber(s) is configured to permit optical measurements of a fluid sample; a vent leading away from the detecting chamber(s); and a liquid blocker between the detecting chamber(s) and an opening of the vent, wherein the liquid blocker permits air to pass therethrough while at the same time restricting liquid flow. A method for analyzing a fluid sample is also provided. The method includes: introducing the fluid sample to the device; contacting the fluid sample with a reagent(s) prior to the fluid sample entering the detecting chamber(s); and making optical measurements of the fluid sample in the detecting chamber(s).

Analysis apparatus with spectrometer

Techniques for localized surface modification for microfluidic applications are provided. In one aspect, a method includes: contacting at least one portion of a surface with at least one tri(m)ethoxysilane-containing solution under conditions sufficient to form at least one silane monolayer having a given contact angle on the surface thereby modifying a flow rate over the surface. The silane monolayer can include a silane derivative selected from: trimethoxysilyl-propoxypolyethyleneoxide (TMS-PPEO), hexadecyl-triethoxysilane (HD-TES), tridecafluoro-1,1,2,2-tetrahydrooctyl)triethoxysilane (TDF-THO-TES), and combinations thereof. A device modified in accordance with the present techniques is also provided.

Localized surface modification for microfluidic applications

A submersible sensor device configured as a small pellet for testing biological and other liquid samples is provided. In one aspect, a sensing device includes: a housing; and one or more sensors contained within the housing, wherein the housing hermetically seals the sensors such that the sensing device is fully submersible in a liquid analyte. A method and system for analysis of a liquid sample using the present sensing device are also provided.

Smart pellet for sample testing

Techniques for optical analysis of fluid samples using sensors and water enhancing agents for in-line measurements with a continuous flow of the fluid samples are provided. In one aspect, a device includes: at least one reagent dispenser located at an introduction point along a conduit, the conduit being configured to contain a flow of a fluid sample; at least one first detector located at a first detection point along the conduit downstream from the introduction point; and at least one second detector located at a second detection point along the conduit downstream from the first detection point, wherein the at least one first detector and the at least one second detector are configured to make optical measurements of the fluid sample. A method employing the device is also provided.

Analysis using optical sensors and signal enhancing agents

Bandage apparatus, methods, and antimicrobial bandages for facilitating wound healing by providing an antimicrobial functionality. A bandage apparatus includes a substrate with a first surface and a second surface opposing the first surface. An attachment mechanism and a nanostructure film are provided on the first surface. The attachment mechanism facilitates removably attaching the substrate to a part of a body comprising a wound. The nanostructure film includes a plurality of nanostructures that contact the wound without puncturing the wound when the substrate is attached to the part of the body comprising the wound.

A method of displaying information relating to an allergen present in a food substance together with a user profile, the method including capturing an image of a scene, segmenting the image to determining at least a segmentation of the food substance in the image, determining a classification of the food substance using the segmentation, determining a presence of the allergen in the food substance using the classification of the food substance and a database of allergens and food substances, determining a risk to a user using the user profile specifying a user sensitivity to the allergen, and displaying an output including a view of the user profile and the image, wherein the image is augmented to identify the presence of the allergen.

Growing community of inventors

Thornhill, Canada

Vince Siu