Quantum Dot Corporation

Invitrogen Corporation

Life Technologies Corporation

Vince E Phillips

Edith Y Wong

Marcel Pierre Bruchez

Andrew Watson

Jennifer Lai

Stephen A Empedocles

Donald A Zehnder

R Hugh Daniels

Marcel Pierre Bruchez, Jr

Jennifer H Lai

Andrew R Watson

Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide and/or an amplification product therefrom are provided. The methods comprise contacting a sample suspected of containing the target polynucleotide with a polynucleotide that can bind specifically thereto; this polynucleotide is conjugated to a substrate, preferably an encoded bead conjugate. An amplification reaction can first be used to produce the amplification product from the target polynucleotide so that it can be used to indirectly assay for the target polynucleotide. An amplification product detection complex and method of forming the same are also provided. The methods are particularly useful in multiplex settings where a plurality of targets are present. Amplification product assay complexes and amplification product assay arrays are also provided, along with methods of forming the same. Kits comprising reagents for performing such methods are also provided.

Loop probe hybridization assay for polynucleotide analysis

The use of semiconductor nanocrystals as detectable labels in various chemical and biological applications is disclosed. The methods find use for detecting a single analyte, as well as multiple analytes by using more than one semiconductor nanocrystal as a detectable label, each of which emits at a distinct wavelength.

Method of detecting an analyte in a sample using semiconductor nanocrystals as a detectable label

Methods of using semiconductor nanocrystals in bead-based nucleic acid assays

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Sunnyvale, CA, United States of America

Vince E Phillips