E.i. Dupont De Nemours and Company

The Dupont Merck Pharmaceutical Company

New England Nuclear Corporation

Vinayakam Subramanyam

Donald J Dumas

Jeffery Scott Thompson

Karen E Linder

Leo J Maheu

Thomas H Tulip

Michael A Patz

Ming-Hong Hung

Harold E Bellis

George C Sonnichsen

Paul L Bergstein

Alan P Carpenter, Jr

Alan B Carpenter, Jr

Algis Rajeckas

Syntheses of fluorinated amide and fluorinated nitrile compounds are improved by use of particular media for the reactions. Fluorinated amide can also be synthesized in high yield in a neat reaction.

Process for synthesizing fluorinated nitrile compounds

A method for preparing a coordination complex of an isonitrile ligand and a radioisotope of Tc, Ru, Co, Pt, Re, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Nb and Ta from a non-radioactive metal adduct of the isonitrite.

Metal-isonitrile adducts for preparing radionuclide complexes

An improved process for preparing benzenesulfonate salts, such as 4-nonanoyloxybenzenesulfonic acid, sodium salt, from an appropriately substituted acid chloride or chloroformate and a hydroxybenzenesulfonic acid in which the reaction is conducted in the presence of a phase transfer catalyst selected from quaternary ammonium and quaternary phosphonium salts.

Process for preparing benzenesulfonate salts

Ether-substituted isonitriles, Tc99m complexes thereof, and processes for myocardial tissue radioimaging using the Tc99m complexes.

Ether isonitriles and radiolabeled complexes thereof

Phenyl esters of substituted acids are prepared by a two-step process in which a phenol derivative is first treated with an acid halide to yield a phenyl ester intermediate, and the intermediate is reacted with an appropriate nucleophile.

Process for preparing phenyl esters of substituted acids

A method for preparing a coordination complex of an isonitrile ligand and a radioisotope of Tc, Ru, Co, Pt, Re, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Nb and Ta from a non-radioactive metal adduct of the isonitrile.

An hepatobiliary imaging agent is disclosed which is a cationic complex of Tc-99m, a cyanate or thiocyanate ion, and a mono or polydentate organic ligand having one or more donor atoms, each with a free-electron pair available for accepting a proton or for complexing with Tc-99m to form a cationic complex. These complexes can provide images of the hepatobiliary transit in as little as ten minutes.

Cationic cyanato and thiocyanato complexes useful as radiodiagnostic

A normally solid, hydrophilic compound capable of binding with Tc-99m to form a cationic complex is provided. The compound has a formula selected from: ##STR1## wherein: R, R', R', R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each independently selected from hydrogen; or substituted or unsubstituted alkyl, alkylene, aryl, alkylaryl, arylalkyl, monocycloalkyl, polycycloalkyl, heterocyclic and carbocyclic groups; and R plus R.sup.i in formula (A) may be taken together to form a cyclic compound;

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Wilmington, DE, United States of America

Vinayakam Subramanyam