Sphaera Pharma Pvt. Ltd.

Sphaera Pharma Pte. Ltd.

Vinayak Tripathi

Sundeep Dugar

Dinesh Mahajan

Kumar Santosh Rai

Ishwar Rakesh Patil

Frank Hollinger Peter

Amit Sharma

Bilash Kuila

The present invention relates to novel triazine compounds of formula (1). The present invention also discloses compounds of formula I along with other pharmaceutical acceptable excipients and use of the compounds to modulate the PI3K/mTOR pathway.

Triazine compounds

A process for synthesis of enatiomerically pure or enatiomerically enriched or racemic mixture of (+ and/or &#x2212;) epicatechin and its intermediates, comprising the steps of: (i) obtaining penta-protected quercetin; (ii) reducing the penta-protected quercetin obtained from step (i); (iii) optionally deprotecting the compound of step (ii); (iv) reducing the compound obtained from step (ii) or step (iii) in the presence of a chiral/achiral reducing agent to obtain a chiral intermediate; (v) deprotecting and/or hydrogenation of the chiral intermediate obtained from step (iv) to obtain (&#x2212;)-epicatechin; (vi) optionally simultaneously deprotecting and by drogenation of the compound obtained from step (ii) to obtain racemic epicatechin.

Approach for synthesis of catechins

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IMT Manesar, India

Vinayak Tripathi