Council of Scientific and Industrial Research

Vinayak Tripathi

Sunil Kumar Chattopadhyay

Sushil Kumar

Koneni Venkata Sashidhara

Veena Prajapati

Arun Kumar Tripathi

Ram Prakash Sharma

Sachin Srivastava

Suchitra Banerjee

Arun Kumar Kukreja

Vijay Kumar Mehta

Manish Kulshrestha

Shipra Agarwal

Synthetic precursors to 4-(P-methoxyphenyl)-2-amino-butane

The present invention relates to a process for the production of (&minus;)3,4-divanillyl tetrahydrofiran of formula (2) which comprises (a) isolating) (&minus;) secoisolariciresinol of formula (1) from the heartwood and roots of by an improved process which consists of partitioning of the alcoholic extract of the heartwood and roots of between water and chlorinated solvent, (b) extracting the chlorinated solvent extract with alkali and (c) isolating (&minus;) secoisolariciresinol from the alkali extract upon neutralization with mineral acid and extracting with organic solvent and (d) crystallizing it from suitable organic solvent, (e) dissolving the isolated (&minus;) secoisolariciresinol in suitable organic solvent and (f) reacting with triphenyl phosphine halide at 0-80&deg; C. for 1-10 hours and (g) isolating (&minus;) 3,4-divanillyl tetrahydrofuran by column chromatography.

Process for the production of (&minus;) 3,4-divanillyl tetrahydrofuran

This invention relates to a process for the production of a compound (&plus;) catechin penta acetate of formula I from tissue cultures which comprises : (a) inoculation of explants on different media compositions supplemented with combinations of auxins (1-5 mg/l) and cytokinins (0.1-1.0 mg/l); (b) incubation of the cultures under continuous light or dark conditions for 4-6 weeks for callus cultures followed by subculturing at 4-6 weeks intervals; (c) harvesting of the calli at different growth phases ranging from 12-36 months; (d) extraction of fresh pulverized calli with polar solvents at room temperature; (e) evaporating the solvent to give a residue; and partitioning of the residue between water and chlorinated solvents and evaporating the solvent to a semisolid mass; (f) subjecting the resultant mass to column chromatography over suitable adsorbent and (g) eluting with organic solvent/mixtures of organic solvents to get (&plus;) catechin penta acetate.

Process for the production of a compound (&plus;) catechin penta acetate useful as a precursor for the production of (&plus;) catechin

The invention provides a process for the preparation of 4-(p-methoxyphenyl)-2-aminobutane represented by structural formula (1) as shown herein below:

Process for preparing novel biologically active synthetic molecule 4-(p-methoxyphenyl)-2-amino-butane

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Lucknow, India

Vinayak Tripathi