Elixir Medical Corporation

Vinayak D Bhat

John Y Yan

Xiaoxia Zheng

Motasim Mahmoud Sirhan

Benjamyn Serna

Joseph Paraschac

Brett W Cryer

Howard Huang

A stent (scaffold) or other luminal prosthesis comprising circumferential structural elements which provide high strength after deployment and allows for scaffold to uncage, and/or allow for scaffold or luminal expansion thereafter. The circumferential scaffold is typically formed from non-degradable material and will be modified to expand and/or uncage after deployment.

Uncaging stent

Devices, systems, and methods are provided including a structure having one or more surfaces configured for internal use within a patient's body and one or more therapeutic compositions comprising one or more active substances including a direct factor Xa inhibitor, and a direct factor IIa inhibitor disposed in or on the structure. The structure is configured to be positioned adjacent an injury site in the patient's body. The one or more active substances optionally include an anti-proliferative agent. The therapeutic composition is formulated to release the one or more active substances to the injury site to provide one or more of inhibit clot formation, promote clot dissolution, inhibit or dissolute inflammation, inhibit vessel injury, increase time before clotting, and/or inhibit cell proliferation.

Anticoagulant compounds and methods and devices for their use

A system for reshaping a valve annulus includes an elongate template having a length along a longitudinal axis and at least one concavity in a generally lateral direction along said length. The pre-shaped template is positioned against at least a region of an inner peripheral wall of the valve annulus, and at least one anchor on the template is advanced into a lateral wall of the valve annulus to reposition at least one segment of the region of the inner peripheral wall of the valve annulus into said concavity. In this way, a peripheral length of the valve annulus can be foreshortened and/or reshaped to improve coaption of the valve leaflets and/or to eliminate or decrease regurgitation of a valve.

Methods and devices for heart valve repair

A stent (scaffold) or other luminal prosthesis comprising circumferential structural elements which provides high strength after deployment and allows for scaffold to uncage, and/or allow for scaffold or luminal expansion thereafter. The circumferential scaffold may be formed from degradable material, or may be formed from non-degradable material and will be modified to expand and/or uncage after deployment.

A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein R, R, R, R, R, R, M, M, M, M, M, Mand Mare each independently a member selected from the group consisting of H, Calkyl, OH and Chydroxyalkyl; R, Rand Rare each independently selected from the group consisting of Calkoxy and OH; Ris a member selected from the group consisting of H, &#x2014;OH, &#x2014;OP(O)Me, &#x2014;O&#x2014;(CH)&#x2014;OH and &#x2014;O&#x2014;(CH)&#x2014;O&#x2014;(CH)&#x2014;CH, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of Land Lare independently selected from the group consisting of: wherein each Mis independently a member selected from the group consisting of Calkyl, OH and Chydroxyalkyl; each of Land Lare independently selected from the group consisting of: and salts, isomers, or N-oxides thereof.

Macrocyclic lactone compounds and methods for their use

Devices and methods are provided for an implantable medical device which is degradable over a clinically relevant period of time. The medical devices may have the form of implants, graft implants, vascular implants, non vascular implants, wound closure implants, sutures, drug delivery implants, biologic delivery implants, urinary tract implants, inter-uterine implants, organ implants, bone implants including bone plates, bone screws, dental implants, spinal disks, or the like. In preferred embodiments, the implantable medical device comprises an implantable luminal prosthesis, such as vascular and non-vascular stents and stents grafts.

Degradable implantable medical devices

A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein R, R, R, R, R, R, M, M, M, M, M, Mand Mare each independently a member selected from the group consisting of H, Calkyl, OH and Chydroxyalkyl; R, Rand Rare each independently selected from the group consisting of Calkoxy and OH; Ris a member selected from the group consisting of H, &#x2014;OH, &#x2014;OP(O)Me, &#x2014;O&#x2014;(CH)&#x2014;OH and &#x2014;O&#x2014;(CH)&#x2014;O&#x2014;(CH)&#x2014;CH, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of Land Lare independently selected from the group consisting of: wherein each Mis independently a member selected from the group consisting of Calkyl, OH and Chydroxyalkyl; each of Land Lare independently selected from the group consisting of: andsalts, isomers, or N-oxides thereof.

Luminal prostheses comprise scaffolds having coatings adhered to at least a portion of their outer surfaces. The surfaces are modified to enhance binding of the coatings. For example, the surfaces may be microblasted, laser treated, chemically etched, exposed to plasma, or exposed to a corona discharge, allowing a polymeric coating to adhere to the scaffold more tightly than in the absence of the surface modification. The coatings can be used to deliver therapeutic or other agents dispersed therein.

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Cupertino, CA, United States of America

Vinayak D Bhat