Advanced Cardiovascular Systems, Inc.

Vinayak Bhat

Syed F A Hossainy

Daryush Mirzaee

Evgenia Mandrusov

Judy A Guruwaiya

Deborra Sanders Millare

Stephen D Pacetti

Keith Edward Fong

Wouter Erik Roorda

Paul M Consigny

Deborra Sanders-Millare

Pinaki Ray

Yung-Ming Chen

Steven Z Wu

Steven B Choi

Jeffrey A Steward

Ashok A Shah

Steven L Mouw

Renee C Slater

Elisa J Aldridge

Andre-Jean S Lundkvist

Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.

Primer coatings for stents with oxide, anionic, or hydroxyl surface moieties

Coatings for implantable devices having a chromium oxide layer and a method of forming the same

Primer coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The primer coatings can include a material with a high content of hydrogen bonding groups, such as some types of epoxy polymers and melamine formaldehydes. Coatings subsequently disposed over the primer coating can be used for the delivery of an active ingredient or a combination of active ingredients.

Primer layer coatings of a material with a high content of hydrogen bonding groups for implantable devices and a method of forming the same

Implantable devices comprising cyanoacrylate primer coatings

Primer coating of inorganic material for implantable devices

Isocyanate coatings for implantable devices and a method of forming the same

High amine content polymer coatings for implantable devices and a method of forming the same

Coatings, particularly primer coatings, for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients. The primer coatings include diacrylates and polyacrylates.

Coating for implantable devices and a method of forming the same

A method of treatment, including separately delivering a treatment agent and a barrier having a binding member to a tissue, the binding member having a property adapted to couple to a surface of the tissue, wherein the barrier is present in an amount sufficient to permit transport of the treatment agent from the tissue at a lower rate than transport in the absence of the barrier component, wherein the barrier is biodegradable and hinders transport of the treatment agent away from the tissue but allows the treatment agent to migrate toward the tissue.

Method of treatment directed to agent retention in biological tissues

An increase in agent residence time at a tissue site is provided for by the presence of a barrier. The barrier is a separate entity from the agent when introduced to the tissue. A binding member is included in the barrier for coupling the barrier to the surface of the tissue. In one embodiment, agent is introduced to the tissue prior to attachment of the barrier to the tissue. In another embodiment, agent is presented after the barrier is positioned on the tissue surface. A delivery vehicle may be used to administer the agent and barrier to a patient.

Method for treatment directed to agent retention in biological tissues

The invention provides bioactive compositions and methods of delivery for ameliorating a vascular diseased state, particularly for the management of stenosis or restenosis following a vascular trauma or disease.

Medicated stents for the treatment of vascular disease

A catheter assembly is provided having a balloon disposed at the distal end thereof. The balloon is capable of being inflated to selectively dilate from a collapsed configuration to an expanded configuration. A syringe assembly is in fluid communication with a delivery lumen of the catheter assembly for allowing a therapeutic substance to be injected into a tissue of a passageway. The syringe assembly includes a portion capable of pivoting from a first position towards a second position when the balloon is being inflated from the collapsed configuration to the expanded configuration. The portion of the syringe assembly is also capable of pivoting from the second position back towards the first position when the balloon is being deflated.

Substance delivery apparatus and a method of delivering a therapeutic substance to an anatomical passageway

A composition and a method for increasing the permeability of membrane junctions or cell membranes for delivery of a drug to target tissues are disclosed. Also disclosed are methods and devices for local drug delivery.

Permeabilizing reagents to increase drug delivery and a method of local delivery

An ethylene vinyl alcohol coating for an implantable device or prosthesis, such as a stent, is provided. Compositions are also provided for coating the implantable device. The compositions can include an ethylene vinyl alcohol copolymer added to an iso-propyl alcohol (IPA)/water solvent. Active agents, such as actinomycin D, can be included in the composition to be carried by the copolymer matrix.

Ethylene vinyl alcohol composition and coating

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Sunnyvale, CA, United States of America

Vinayak Bhat