Case Western Reserve University

Vinay Varadan

Anant Madabhushi

Sanford D Markowitz

Nathaniel Braman

Prateek Prasanna

Won Jin Ho

Lyndsay Harris

Stephen P Fink

Salendra Singh

A method of treating intestinal gastrointestinal, or bowel disorders in a subject in need thereof includes administering to the subject a therapeutically effective amount of 15-PGDH inhibitor alone or in combination with a corticosteroid and/or TNF alpha antagonist.

Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof

Methods, apparatus, and other embodiments distinguish disease phenotypes and mutational status using co-occurrence of local anisotropic gradient orientations (CoLIAGe) and Laws features. One example apparatus includes a set of circuits that acquires a radiologic image (e.g., MRI image) of a region of tissue demonstrating breast cancer, computes a gradient orientation for a pixel in the MRI image, computes a significant orientation for the pixel based on the gradient orientation, constructs a feature vector that captures a discretized entropy distribution for the image based on the significant orientation, extracts a set of texture features from the MRI image, and classifies the phenotype of the breast cancer based on the feature vector and the set of texture features. Embodiments of example apparatus may generate and display a heatmap of entropy values for the image. Example methods and apparatus may operate substantially in real-time, or may operate in two, three, or more dimensions.

Entropy-based radiogenomic descriptions on magnetic resonance imaging (MRI) for molecular characterization of breast cancer

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Westlake, OH, United States of America

Vinay Varadan