Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Vilmos Simonidesz

Gabor Kovacs

Istvan Stadler

Csaba Szantay

Istvan Szekely

Istvan Tomoskozi

Jozsef Ivanics

Marianna Lovasz Nee Gaspar

Peter S Kormoczy

Geza Galambos

Agnes Papp Nee Behr

Julia Remport Nee Radoczi

Zsuzsa Visky Nee Gombos

Lajos T Nagy

Sandor Virag

Gyorgy Lugosi

Tamas U Kallay

Laszlo Simandi

Lajos Novak

Karoly Horvath

Istvan Pallagi

Gabor Besenyei

Erzsebet Szalay

Istvan Jelinek

Peter Gyory

Ildiko Szilagyi

Krisztina Kekesi

Zsuzsanna Nad

Judit Skopal

Julia Der Nee Foldvary

Gaza Galambos

Jozsef Aszodi

Ilona Santa Nee Singola

Borbala Keresztes Nee Ordog

Marta Lugosi

Julia Nee Remport

Zsuzsa Nee Visky

Borbala Nee Keresztes

Borbala Keresztesnee Ordog

Process for the preparation of pharmaceutical compositions

New PGI.sub.1 derivatives are disclosed as well as a process for the preparation thereof, pharmaceutical compositions containing same and methods of treatment employing same. The new compounds are useful to inhibit blood platelet aggregation induced by ADF, arachidic acid, or collagen, as well as to improve blood circulation and to inhibit gastric acid secretion.

5-Substituted-4-oxo-PGI.sub.1 derivatives, PGI.sub.1 compounds of

The invention relates to a process for the preparation of novel 4-oxo-PGI.sub.2 derivatives of formula I ##STR1## where (a) compounds of formula III ##STR2## are oxidized, then the obtained 5-substituted-4-oxo-PGI.sub.1 derivatives of general formula II ##STR3## are eliminated by the splitting off of the W-H-molecule, or (b) the compounds of formula IV ##STR4## are reacted in a solvent in the presence of a catalyst with compounds of general formula V ##STR5## then the obtained compounds of formula I are transformed if desired by saponification, hydrolysis, salt formation, insertion of a protection group to another compound which belongs to the compounds of formula I, too. The pharmaceutical products of the invention can be used for the treatment of circulatory diseases, they inhibit the aggregation of blood plaques, dilate the bronchi and inhibit the secretion of gastric acid.

4-Oxo-PGI.sub.2 compounds, their use in inhibition of thrombii and their

The invention relates to new optically active or racemic 13-thia-prostacycline derivatives of the Formula I ##STR1## wherein R.sup.1 is hydrogen, a pharmaceutically acceptable cation or a straight or branched chain alkyl group having 1-5 carbon atoms;

13-Thia-prostacycline derivatives

New PGI.sub.2 derivatives and a process for their preparation are disclosed of the formula (I) ##STR1## wherein Q is hydrogen, a pharmacologically acceptable cation, or lower alkyl;

7-Oxo-PGI.sub.2 -derivatives and process for the preparation thereof and

A process for the preparation of optically active or racemic lactone diol derivatives of the formula ##STR1## (for use as intermediates in the Corey prostaglandin synthesis). Optically active or racemic lactone diol derivatives are inclosed, in which

Process for making bicyclic lactone derivatives for use as intermediates

A process for the preparation of bicyclic enon compounds in which a lactone diol is selectively oxidized to obtain a hydroxy-aldehyde with one hydroxyl group and, without isolation, the hydroxy-aldehyde is reacted with a phosphorus compound. The reaction product can be acylated or silylated.

Process for the preparation of bicyclic enone compounds

A compound of the formula is disclosed. ##STR1## wherein R.sup.3 and R.sup.4 are the same or different and are each hydrogen, lower alkanoyl, lower alkanoyl substituted by 1, 2, or 3 halogen atoms, or R.sup.3 and R.sup.4 together form an ##STR2## group in which R.sup.5 and R.sup.6 are the same or different and are each hydrogen, alkyl or aryl as well as a process for the preparation thereof.

Bicyclic lactone derivatives employed as intermediates in the synthesis

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Budapest, Hungary

Vilmos Simonidesz