Dompe S.p.a.

Other

Vilma Sabbatini

Marcello Allegretti

Maria Candida Cesta

Francesco Colotta

Riccardo Bertini

Cinzia Bizzarri

Carmelo A Gandolfi

Gianfranco Caselli

Marco Mantovanini

Giulio Agostino Gandolfi, Legal Representative

Maria Carla Gandolfi, Legal Representative

Arrigo Aldo Gandolfi, Legal Representative

Janete Peloia Barroso Gandolfi, Legal Representative

Ginfranco Caselli

Stefano Porzio

N-(2-aryl-propionyl)-amides of formula (I) are described.  The process for their preparation and pharmaceutical preparations thereof are also described. The amides of the invention are useful in the prevention and treatment of tissue damage due to the exacerbate recruitment of polymorphonuclear neutrophils (leukocytes PMN) at the inflammatory sites. In particular, the invention relates to the R enantiomers of N-(2-aryl-propionyl)amides of formula (I) for use in the inhibition of the chemotaxis of neutrophils induced by IL-8. The compounds of the invention are used in the treatment of psoriasis, ulcerative cholitis, glomerular nephritis, acute respiratory insufficiency, idiopathic fibrosis, and rheumatoid arthritis.

Amides, useful in the inhibition of IL-8-induced chemotaxis of neutrophils

N-(2-aminoaryl-propionyl)-amides of formula (1) are described.  The process for their preparation and pharmaceutical preparations thereof are also described. The amides of the invention are useful in the prevention and treatment of tissue damage due to the exacerbate recruitment of polymorphonuclear neutrophils (leukocytes PMN) at the inflammatory sites. In particular, the invention relates to the R enantiomers of 2-(aminoaryl)-propionyl amides of formula (1) for use in the ihibition of the chemotaxis of neutrophils induced by IL-8. The compounds of the invention are used in the treatment of psoriasis, ulcerative cholitis, glomerular nephritis, acute respiratory insufficiency, idiopathic fibrosis, and rheumatoid arthritis.

Amide of R-2-(aminoaryl)-propionic acid for use in the prevention of leucocyte activation

The compounds of formula 1wherein R and Rare as defined in the disclosure, are useful in the prevention and treatment of tissue damage due to exacerbated recruitment of polymorphonuclear neutrophils (PMN leukocytes) at the inflammatory sites.

N-(2-aryl-propionyl)-sulfonamides and pharmaceutical preparations containing them

The compounds of formula 1,wherein R and Rare as defined in the disclosure, are useful in the prevention and treatment of tissue damage due to exacerbated recruitment of polymorphonuclear neutrophils (PMN leukocytes) at the inflammatory sites.

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L'Aquila, Italy

Vilma Sabbatini