Emulate, Inc.

Cedars-sinai Medical Center

Ville Kujala

Christopher David Hinojosa

Geraldine A Hamilton

Norman Wen

Josiah Daniel Sliz

S Jordan Kerns

Jacob Fraser

Catherine Karalis

Dhruv Sareen

Gang Luo

Hyoungshin Park

Sonalee Barthakur

Sauveur Jeanty

Brian Zuckerman

Tanvi Shroff

Kyung-Jin Jang

Ananth Nookala

Donald Mckenzie

Hyoung Shin Park

Berhan Mandefro

Anjoscha Kaus

The present invention relates to microfluidic fluidic devices, methods and systems for use in identifying epigenetic signatures in a range of sample types, e.g., cells established on a 'chip' (including but not limited to single cell samples, cell populations, C cell layers and whole tissues, such as a biopsy), immune cells, cfDNA, exosomes, and the like. More specifically, in some embodiments, a microfluidic chip containing a sample is contacted with a test compound (e.g. DNA altering test compound, an RNA expression altering test compound, etc.) for use in providing a diagnostic epigenetic signature for that type of sample (or cell type) exposed to that specific test compound. In some embodiments, after contact with a test compound, effluent fluids (e.g. fluids exiting the “chip” that contacted the cells) are derived for testing as a “virtual blood draw.” In some embodiments, epigenetic signatures include (but are not limited to) identifying specific combinations of modifications of chromosomes and specific modifications of DNA.

Organs-on-chips as a platform for epigenetics discovery

The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Chip.

Microfluidic kidney-on-chip

Growing community of inventors

Medford, MA, United States of America

Ville Kujala