Bostongene Corporation

Viktor Svekolkin

Ekaterina Postovalova

Alexander Bagaev

Ravshan Ataullakhanov

Nikita Kotlov

Zoia Antysheva

Ilia Galkin

Arina Varlamova

Pavel Ovcharov

Anton Karelin

Daria Kiriy

Anton Sivkov

Ivan Kozlov

Aleksandr Sarachakov

Described herein in some embodiments is a method comprising: obtaining expression data previously obtained by processing a biological sample obtained from a subject; processing the expression data using a hierarchy of machine learning classifiers corresponding to a hierarchy of molecular categories to obtain machine learning classifier outputs including a first output and a second output, the hierarchy of molecular categories including a parent molecular category and first and second molecular categories that are children of the parent molecular category in the hierarchy of molecular categories, the hierarchy of machine learning classifiers comprising first and second machine learning classifiers corresponding to the first and second molecular categories; and identifying, using at least some of the machine learning classifier outputs including the first output and the second output, at least one candidate molecular category for the biological sample.

Hierarchical machine learning techniques for identifying molecular categories from expression data

Techniques for processing multiplexed immunofluorescence (MxIF) images. The techniques include obtaining at least one MxIF image of a same tissue sample, obtaining information indicative of locations of cells in the at least one MxIF image, identifying multiple groups of cells in the at least one MxIF image at least in part by determining feature values for at least some of the cells using the at least one MxIF image and the information indicative of locations of the at least some cells in the at least one MxIF image and grouping the at least some of the cells into the multiple groups using the determined feature values, and determining at least one characteristic of the tissue sample using the multiple cell groups.

Techniques for determining tissue characteristics using multiplexed immunofluorescence imaging

Techniques for determining one or more characteristics of a biological sample using rankings of gene expression levels in expression data obtained using one or more sequencing platforms is described. The techniques may include obtaining expression data for a biological sample of a subject. The techniques further include ranking genes in a set of genes based on their expression levels in the expression data to obtain a gene ranking and determining using the gene ranking and a statistical model, one or more characteristics of the biological sample.

Gene expression analysis techniques using gene rankings and statistical models for identifying biological sample characteristics

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Ulyanovsk, Russia

Viktor Svekolkin