Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag

Corus Pharma, Inc.

Teva Gyógyszergyár Zártkörún Müködö Részvénytársaság

Viktor Gyollai

Csaba Szabo

Claude Singer

Istvan Bodi

Judith Aronhime

Adrienne Kovacsne-Mezei

Ehud Amir

Sandor Janos Molnar

Csilla Nemethne Racz

Szabolcs Salyi

Erzsebet Meszaros Sos

Micahel Pinchasov

An amorphous pimecrolimus and processes for providing an amorphous pimecrolimus are provided.

Non-hygroscopic and powdery amorphous pimecrolimus

The invention relates to the &#x3b2; polymorph of Aztreonam, which contains less than 2.5% by weight residual solvent and to a process of making said polymorph. In the process of the invention, a polymorph of Aztreonam is dissolved in an absolute Calcohol in the presence of a base to form a solution, an acid is added to the solution, and the solution is stirred efficiently.

Aztreonam &#x3b2; polymorph with very low residual solvent content

The present invention relates to the L-lysine salt of aztreonam and methods for making the L-lysine salt of aztreonam.

Aztreonam L-lysine and methods for the preparation and analysis thereof

The present invention provides a process for the preparation of pimecrolimus from ascomycin in which ascomycin is reacted with a conversion reagent that converts ascomycin to its activated derivative at C-32. The activated ascomycin is then reacted with chloride ion. The process of the invention requires fewer process steps than prior art processes, and does not require the protection of the ascomycin C-24 hydroxyl group or the purification of the activated ascomycin derivative.

Methods of preparing pimecrolimus

Aztreonam L-lysine and methods for the preparation thereof

The invention relates to a process for the synthesis of Aztreonam. Specifically, the process entails hydrolyzing [3S-[3&#x3b1;(Z),4&#x3b2;]]-3-[[(2-amino-4-thiazolyl)[(1-t-butoxycarbonyl-1-methylethoxy)imino]acetyl]amino]-4-methyl-2-oxo-1-azetidinesulfonic acid (t-Bu Aztreonam) to form Aztreonam.

Preparation of Aztreonam

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Debrecen, Hungary

Viktor Gyollai