Reg Life Sciences, LLC

Genomatica, Inc.

Vikranth Arlagadda

Zhihao Hu

Elizabeth J Clarke

Eli S Groban

Louis G Hom

Derek L Greenfield

Baolong Zhu

Murtaza F Alibhai

Na Trinh

Sungwon Lee

Xuezhi Li

Andreas W Schirmer

Haibo Wang

Noah Helman

Alma Itzel Ramos-Solis

Fernando A Sanchez-Riera

Scott Allen Frykman

Fernando A Sanchez-riera

Elizabeth Clarke

The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.

Microbial production of fatty diols

The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, and engineered host cells for producing fatty acids and derivates of fatty acids such as acyl-CoA, terminal olefins, fatty aldehydes, fatty alcohols, alkanes, alkenes, wax esters, ketones and internal olefins through altered expression of the transcription factor, fadR.

Methods and compositions for improved production of fatty acids and derivatives thereof

The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.

Car enzymes and improved production of fatty alcohols

The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.

Methods and compositions related to thioesterase enzymes

Methods and compositions, including nucleotide sequences, amino acid sequences, and host cells, for producing fatty alcohols are described.

Methods and compositions for producing fatty alcohols

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South San Francisco, CA, United States of America

Vikranth Arlagadda