Clear Creek Bio, Inc.

Columbia University

Vikram S Kumar

Ping Huang

David Paul Hesson

Mo Jia

Xianjun You

Rafael Yuste

Robert C Froemke

The invention provides therapeutic compositions that contain an inhibitor of dihydroorotate dehydrogenase (DHODH) and promote sustained elevation of dihydroorotate (DHO) levels in a patient. The compositions are useful for treating disorders associated with unregulated DHODH activity, such as acute myeloid leukemia. The invention also provides methods of determining therapeutically effective doses of compositions that contain a DHODH inhibitor. The invention further provides methods of synthesis of 2-(2'-halo-1-1′-biphenyl-4-yl)-quinoline carboxylic acids, which are useful as DHODH inhibitors.

Compositions and methods for inhibiting dihydroorotate dehydrogenase

The invention provides therapeutic compositions that contain an inhibitor of dihydroorotate dehydrogenase (DHODH) and promote sustained elevation of dihydroorotate (DHO) levels in a patient. The compositions are useful for treating disorders associated with unregulated DHODH activity, such as acute myeloid leukemia. The invention also provides methods of determining therapeutically effective doses of compositions that contain a DHODH inhibitor. The invention further provides methods of synthesis of 2-(2'-halo-1-1&#x2032;-biphenyl-4-yl)-quinoline carboxylic acids, which are useful as DHODH inhibitors.

Disclosed is a method for analyzing a sequence of data arrays. A selection of at least one type of region of interest and at least one region of interest from said data arrays is made. The sequence of data arrays are then transformed into a simplified data array. Events of interest in the selected regions of interest are then detected and stored in a second simplified data array. The data is then analyzed to determine relationships between the detected events of interest

Growing community of inventors

Boston, MA, United States of America

Vikram S Kumar