Council of Scientific and Industrial Research

Other

Zandu Pharmaceutical Works Ltd.

Vikram Bhardwaj

Naresh Kumar Satti

Krishan Avtar Suri

Sukhdev Swami Handa

Vishwa Nath Gupta

Om Parkash Suri

Bal Krishan Chandan

Kasturi Lal Bedi

Anamika Khajuria

Anpurna Kaul

Om Prakash Suri

Girish G Parikh

Raman Krishnamurthy

Prabhakar Kulhar

Ulhas Salunkhe

Bupinder Singh

Ghulam Nabi Qazi

Ajit Kumar Saxena

Bishan Datt Gupta

Bupinder Singh Jaggi

Neelam Sharma

Bhupinder Singh

Jyotsna Suri

Madalsa Bargotra

V N Gupta

The present invention relates to a synergistic formulation comprising trans-tetracos-15-enoic acid (t-TCA) and andrographolide (AP) in the ratio ranging between 1:7 to 7:1 (w/w), useful in hepatoprotection; and a process for the preparation of a synergistic formulation comprising trans-tetracos-15-enoic acid (t-TCA) and andrographolide (AP) useful in hepatoprotection, said process comprising steps of grounding the particles of the t-TCA and AP into fine particles, mixing the fine particles in ratio ranging between 1:7 to 7:1 (w/w), and grinding the mixture to obtain formulation, and also, a method of hepatoprotection of a subject using the synergistic formulation comprising trans-tetracos-15-enoic acid (t-TCA) and andrographolide (AP), said method comprising the steps of administering the formulation to the subject.

Synergistic hepatoprotective composition and a method thereof

The present invention relates to a pharmaceutical composition comprising a bioactive constituent trans-tetracos-15-enoic acid and a process for the isolation of tetracos-15-enoic acid from the plantalong with a method of treatment for hepatotoxicity.

Pharmaceutical composition and process for isolation of trans-tetracos-15-enoic acid and method of treatment for hepatotoxicity

The present invention relates to a synergistic hepatoprotective pharmaceutical composition comprising an effective amount of trans-tetracos-15-enoic acid (TCA) and Apocynin (APO), the present invention also relates to a method of treatment for hepatotoxicity in mammals and humans.

Synergistic composition of trans-tetracos-15-enoic acid and Apocynin and method of treatment for hepatotoxicity

The present invention relates to a process for the preparation of trans-alkenoic acids of general formula CH&#x2014;(CH)n&#x2014;CH&#x2550;(CH)mCOH where n=4 to 9 m=8 to 16. More particularly, the present invention relates to a process for the preparation of trans-tetracos-15-enoic acid, which is a bioactive constituent possessing dose-related hepatoprotective activity. The present invention also relates to the use thereof for hepatoprotection.

Process for the synthesis of trans-alkenoic acids, use thereof

The present invention relates to a process for the isolation of a novel oligospirostanoside structurally constructed as 3-0-&lsqb;&agr;-L-rhamnopyranosyl-(1&rarr;2)-&agr;-L-rhamnopyranosyl-(1&rarr;4)-0-&bgr;-D-glucopyranosyl&rsqb;-25(S)-5&bgr; spirostan-3&bgr;-ol isolated from and biologically evaluated as a potent immunomodulatory agent.

Process for the isolation of novel oligospirostanoside

The present invention relates to a novel oligospirostanoside having the structure 3-0-&lsqb;&agr;-L-rhamnopyranosyl-(1&rarr;2)-&agr;-L-rhamnopyranosyl-(1&rarr;4)-0-&bgr;-D-glucopyranosyl&rsqb;-25(S)-5&bgr;-spirostan-3&bgr;-ol isolated from and to a pharmaceutical composition containing the novel oligospirostanoside and to a method for immunomodulation using said oligospirostanoside by administering a pharmaceutically effective amount of said novel oligospirostanoside.

Oligospirostanoside, pharmaceutical composition containing novel oligospirostanoside and method for immunomodulation using said oligospirostanoside

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Jammu, India

Vikram Bhardwaj