Jubilant Life Sciences Limited

Jubilant Generics Limited

Vikas Bansal

Dharam Vir

Sujay Biswas

Mukesh Masand

Shailendra Kumar Dubey

Sushil Kumar Dubey

Mokkapati Umamaheshwar Prasad

Anjul Kumar

Rohit Chakravarty

Sankareswaran Srimurugan

Atulya Kumar Panda

Danish Jamshad

Bidyut Biswas

Ashish Kumar Gupta

Kamaljeet Pannu

The present invention provides an improved process for the preparation of exametazime, which is used as ligand in preparation of technetium-99m complex. 

Process for the preparation of exametazime

The present invention provides a novel process for the preparation of substituted optically pure (S)-(+)- or (R)-(&#x2212;)-10-hydroxy-dihydrodibenz[b,f]azepines or derivatives thereof, starting from 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepines using boronate esters or their derivatives. The present invention also provides use of thus prepared (S)-(+)- or (R)-(&#x2212;)-10-hydroxy-dihydrodibenz[b,f]azepines for the preparation of their ester such as (S)-(&#x2212;)-10-acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide or (R)-(+)-10-acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide. The present invention also provides novel solid state crystalline forms J, J, J, Jand amorphous form of eslicarbazepine and the process for the preparation thereof. Also, the present invention provides novel solid state crystalline form and amorphous form of eslicarbazepine acetate and the process for the preparation thereof. The novel solid state forms of eslicarbazepine are useful for the preparation of derivatives of eslicarbazepine such as eslicarbazepine acetate.

Process for the preparation of (S)-(+)- or (R)-(-)-10-hydroxy dihydrodibenz[B,F]azepines by enantioselective reduction of 10,11-dihydro-10-OXO-5H-dibenz[B,F]azepines and polymorphs thereof

The present invention provides a novel process and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren, or a salt thereof, preferably Aliskiren hemifumarate.

Process for the preparation of aliskiren

Disclosed herein are novel intermediates and process for large scale production of (S)-3-[(1-dimethylamino)ethyl]phenyl-N-ethyl-N-methyl-carbamate (rivastigmine) or its pharmaceutically acceptable salts employing the novel intermediates. Further provided are methods for producing the novel intermediates thereof.

Process for producing (S)-3-[(1-dimethylamino)ethyl] phenyl-N-ethyl-N-methyl-carbamate via novel intermediates

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Uttar Pradesh, India

Vikas Bansal