Megafine Pharma (p) Ltd.

Vijayvitthal Thippannachar Mathad

Bhushan Sudhakar Pandit

Navnath Chintaman Niphade

Kunal Madhav Jagtap

Gorakshanath Balasaheb Shinde

Sharad Subhash Ippar

Shrikant Prataprao Deshmukh

Anil Chaturlal Mali

P Raghvendra Kumar

Shashikant Baburao Landge

Ragavendra Kumar Panchangam

A method for the preparation of solifenacin by reacting quinuclidin-3-ol and bis (aryl) carbonate to form (3R)-1-azabicyclo[2.2.2]oct-3-yl 4-aryl carbonate of formula (IVa); and treating (3R)-1-azabicyclo[2.2.2]oct-3-yl 4-aryl carbonate of formula (IVa) with (1S)-1-phenyl- 1,2,3,4-tetrahydroisoquinoline of formula (V) in an inert atmosphere to form a Solifenacin base, which is converted into its pharmaceutically acceptable salts. The invention also provides a compound, (3R)-1-azabicyclo[2.2.2]oct-3-yl 4-aryl carbonate of formula (IVa), which is used as an intermediate for the preparation of Solifenacin base and a process for the preparation thereof.

Method for the preparation of solifenacin and intermediate thereof

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Maharashtra, India

Vijayvitthal Thippannachar Mathad